| SP | Bautista, D.Bautista, Denny >> | 26 | 2005 | R | 50 | 18 | 18 | 2 | 5 | 5.20 | .357 | 1.62 | 9.4 | 5.2 | 6.1 | 88.1 | 92 | 52 | 51 | 9 | 51 | 60 | 0 | 0 | 0 | 0 | 3 | 4 | 9 | 4.84 |
| SP | Hernandez, R.Hernandez, Runelvys >> | 28 | 2005 | R | 32 | 17 | 17 | 1 | 9 | 4.82 | .346 | 1.57 | 10.5 | 3.6 | 6.0 | 97.0 | 113 | 52 | 52 | 13 | 39 | 65 | 0 | 0 | 0 | 0 | 9 | 2 | 2 | 4.67 |
| SP | Howell, J.Howell, J.P. >> | 23 | 2005 | L | 28 | 17 | 17 | 1 | 9 | 7.97 | .398 | 1.91 | 11.2 | 6.1 | 7.0 | 66.2 | 82 | 59 | 59 | 10 | 45 | 51 | 0 | 0 | 0 | 0 | 2 | 5 | 3 | 5.70 |
| SP | Greinke, Z.Greinke, Zack >> | 23 | 2005 | R | 21 | 17 | 17 | 7 | 5 | 5.23 | .321 | 1.36 | 9.9 | 2.5 | 5.6 | 94.2 | 103 | 57 | 55 | 13 | 26 | 58 | 0 | 0 | 0 | 0 | 8 | 5 | 4 | 4.55 |
| SP | Anderson, B.Anderson, Brian >> | 34 | 2005 | L | 17 | 17 | 17 | 4 | 4 | 3.61 | .303 | 1.29 | 9.7 | 2.0 | 5.0 | 89.2 | 96 | 39 | 36 | 9 | 20 | 49 | 0 | 0 | 0 | 0 | 6 | 1 | 0 | 3.92 |
| CL | MacDougal, M.MacDougal, Mike >> | 29 | 2005 | R | 71 | 44 | 0 | 3 | 6 | 4.41 | .307 | 1.29 | 8.3 | 3.3 | 7.3 | 49.0 | 45 | 25 | 24 | 3 | 18 | 40 | 0 | 16 | 6 | 0 | 0 | 2 | 2 | 3.39 |
| RP | Sisco, A.Sisco, Andrew >> | 23 | 2005 | L | 64 | 47 | 0 | 4 | 3 | 6.18 | .361 | 1.69 | 10.4 | 5.0 | 10.5 | 59.2 | 68 | 41 | 41 | 5 | 33 | 69 | 0 | 0 | 3 | 0 | 0 | 0 | 1 | 3.44 |
| RP | Burgos, A.Burgos, Ambiorix >> | 22 | 2005 | R | 63 | 48 | 0 | 2 | 1 | 3.25 | .305 | 1.30 | 7.3 | 4.6 | 8.1 | 63.2 | 51 | 24 | 23 | 1 | 32 | 57 | 0 | 0 | 4 | 0 | 0 | 1 | 4 | 2.97 |
| RP | Jensen, R.Jensen, Ryan >> | 31 | 2005 | R | 21 | 33 | 0 | 5 | 2 | 6.50 | .390 | 1.89 | 14.3 | 2.9 | 5.7 | 44.1 | 70 | 36 | 32 | 5 | 14 | 28 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 4.23 |