| SP | McCarthy, B.McCarthy, Brandon >> | 23 | 2005 | R | 91 | 18 | 18 | 9 | 4 | 2.69 | .293 | 1.21 | 7.9 | 3.1 | 6.7 | 113.2 | 99 | 38 | 34 | 9 | 39 | 84 | 0 | 0 | 0 | 0 | 12 | 3 | 2 | 3.66 |
| SP | Contreras, J.Contreras, Jose >> | 35 | 2005 | R | 83 | 17 | 17 | 8 | 6 | 3.08 | .289 | 1.21 | 8.0 | 2.8 | 7.9 | 117.0 | 104 | 41 | 40 | 7 | 37 | 103 | 1 | 0 | 0 | 0 | 13 | 2 | 8 | 3.02 |
| SP | Buehrle, M.Buehrle, Mark >> | 27 | 2005 | L | 79 | 17 | 17 | 6 | 10 | 5.41 | .323 | 1.40 | 10.7 | 1.9 | 7.1 | 121.1 | 144 | 76 | 73 | 18 | 26 | 95 | 2 | 0 | 0 | 0 | 4 | 4 | 3 | 4.11 |
| SP | Garcia, F.Garcia, Freddy >> | 30 | 2005 | R | 75 | 17 | 17 | 6 | 8 | 5.38 | .324 | 1.40 | 10.2 | 2.4 | 4.9 | 115.1 | 130 | 76 | 69 | 16 | 31 | 62 | 2 | 0 | 0 | 0 | 8 | 5 | 8 | 4.67 |
| SP | Garland, J.Garland, Jon >> | 27 | 2005 | R | 74 | 17 | 17 | 4 | 9 | 5.17 | .322 | 1.40 | 9.9 | 2.8 | 5.4 | 109.2 | 120 | 74 | 63 | 14 | 34 | 65 | 2 | 0 | 0 | 1 | 8 | 2 | 0 | 4.47 |
| RP | Vizcaino, L.Vizcaino, Luis >> | 32 | 2006 | R | 81 | 48 | 0 | 2 | 0 | 1.08 | .219 | 0.84 | 4.9 | 2.7 | 10.1 | 33.1 | 18 | 6 | 4 | 3 | 10 | 37 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 2.85 |
| RP | Hermanson, D.Hermanson, Dustin >> | 34 | 2005 | R | 77 | 12 | 0 | 0 | 0 | 3.18 | .333 | 1.50 | 8.2 | 5.7 | 4.9 | 11.1 | 10 | 4 | 4 | 0 | 7 | 6 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 3.82 |
| RP | Marte, D.Marte, Damaso >> | 31 | 2006 | L | 60 | 28 | 0 | 1 | 2 | 4.05 | .326 | 1.45 | 8.6 | 4.5 | 9.5 | 20.0 | 19 | 12 | 9 | 1 | 10 | 21 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 3.05 |
| SP | Hernandez, O.Hernandez, Orlando >> | 41 | 2006 | R | 71 | 6 | 0 | 2 | 0 | 1.42 | .309 | 1.30 | 9.0 | 2.9 | 7.2 | 25.1 | 25 | 5 | 4 | 3 | 8 | 20 | 0 | 0 | 0 | 0 | 0 | 1 | 2 | 4.04 |
| CL | Politte, C.Politte, Cliff >> | 32 | 2005 | R | 96 | 30 | 0 | 2 | 6 | 3.64 | .310 | 1.31 | 8.1 | 4.0 | 8.1 | 29.2 | 26 | 13 | 12 | 3 | 13 | 26 | 0 | 20 | 2 | 0 | 0 | 1 | 0 | 4.00 |