| SP | Bonderman, J.Bonderman, Jeremy # >> | 24 | 2006 | R | 71 | 18 | 18 | 5 | 5 | 5.16 | .349 | 1.55 | 11.1 | 2.9 | 7.5 | 106.1 | 131 | 62 | 61 | 15 | 34 | 88 | 1 | 0 | 0 | 0 | 8 | 6 | 2 | 4.31 |
| SP | Robertson, N.Robertson, Nate >> | 29 | 2006 | L | 65 | 17 | 17 | 9 | 2 | 2.72 | .291 | 1.20 | 7.8 | 3.0 | 6.1 | 116.0 | 100 | 35 | 35 | 7 | 39 | 78 | 1 | 0 | 0 | 1 | 12 | 4 | 3 | 3.55 |
| SP | Verlander, J.Verlander, Justin # >> | 23 | 2006 | R | 63 | 17 | 17 | 4 | 9 | 5.31 | .344 | 1.50 | 10.5 | 3.1 | 5.6 | 105.0 | 122 | 66 | 62 | 18 | 36 | 65 | 0 | 0 | 0 | 0 | 8 | 7 | 4 | 5.22 |
| SP | Douglass, S.Douglass, Sean >> | 27 | 2005 | R | 57 | 17 | 17 | 3 | 8 | 5.77 | .357 | 1.63 | 10.3 | 4.4 | 7.3 | 78.0 | 89 | 53 | 50 | 10 | 38 | 63 | 0 | 0 | 0 | 0 | 2 | 3 | 3 | 4.63 |
| SP | Maroth, M.Maroth, Mike >> | 29 | 2005 | L | 48 | 18 | 17 | 9 | 3 | 3.77 | .327 | 1.43 | 10.0 | 2.9 | 5.4 | 114.2 | 127 | 51 | 48 | 4 | 37 | 69 | 0 | 0 | 0 | 0 | 11 | 3 | 7 | 3.30 |
| RP | Zumaya, J.Zumaya, Joel >> | 22 | 2006 | R | 89 | 45 | 0 | 2 | 4 | 4.79 | .306 | 1.29 | 7.4 | 4.2 | 10.2 | 62.0 | 51 | 38 | 33 | 10 | 29 | 70 | 0 | 0 | 2 | 0 | 0 | 2 | 4 | 4.34 |
| RP | Urbina, U.Urbina, Ugueth >> | 32 | 2005 | R | 89 | 42 | 0 | 2 | 3 | 3.15 | .294 | 1.20 | 6.6 | 4.4 | 9.0 | 45.2 | 33 | 16 | 16 | 3 | 22 | 45 | 0 | 1 | 0 | 0 | 0 | 2 | 2 | 3.47 |
| RP | Rodney, F.Rodney, Fernando >> | 29 | 2006 | R | 85 | 28 | 0 | 3 | 1 | 2.25 | .226 | 0.81 | 5.3 | 2.0 | 5.6 | 32.0 | 19 | 8 | 8 | 1 | 7 | 20 | 0 | 0 | 0 | 0 | 0 | 2 | 1 | 3.00 |
| RP | Walker, J.Walker, Jamie >> | 35 | 2006 | L | 72 | 47 | 0 | 2 | 1 | 5.18 | .317 | 1.36 | 10.6 | 1.6 | 5.5 | 33.0 | 39 | 21 | 19 | 5 | 6 | 20 | 0 | 2 | 2 | 0 | 0 | 1 | 1 | 4.39 |
| RP | Spurling, C.Spurling, Chris >> | 29 | 2005 | R | 79 | 26 | 0 | 1 | 4 | 2.78 | .242 | 0.90 | 7.0 | 1.1 | 4.8 | 32.1 | 25 | 10 | 10 | 4 | 4 | 17 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 4.13 |
| RP | Percival, T.Percival, Troy >> | 37 | 2005 | R | 75 | 25 | 0 | 0 | 1 | 5.90 | .315 | 1.34 | 6.8 | 5.3 | 6.2 | 29.0 | 22 | 19 | 19 | 5 | 17 | 20 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 5.72 |
| CL | Farnsworth, K.Farnsworth, Kyle >> | 30 | 2005 | R | 96 | 32 | 0 | 0 | 5 | 1.93 | .285 | 1.13 | 5.3 | 5.1 | 10.7 | 32.2 | 19 | 7 | 7 | 1 | 18 | 38 | 0 | 14 | 0 | 0 | 0 | 2 | 0 | 2.91 |