| SP | Liriano, F.Liriano, Francisco >> | 23 | 2006 | L | 75 | 27 | 27 | 3 | 11 | 5.36 | .328 | 1.44 | 9.3 | 3.8 | 9.1 | 132.2 | 136 | 81 | 79 | 26 | 55 | 134 | 0 | 0 | 0 | 0 | 6 | 3 | 5 | 4.85 |
| SP | Hendricks, K.Hendricks, Kyle >> | 26 | 2016 | R | 74 | 27 | 27 | 7 | 9 | 4.68 | .321 | 1.40 | 9.2 | 3.4 | 7.3 | 148.0 | 151 | 80 | 77 | 26 | 56 | 120 | 0 | 0 | 0 | 0 | 13 | 3 | 2 | 4.86 |
| SP | Kluber, C.Kluber, Corey >> | 31 | 2017 | R | 95 | 26 | 26 | 13 | 8 | 3.23 | .304 | 1.29 | 8.5 | 3.2 | 10.0 | 183.2 | 172 | 72 | 66 | 24 | 65 | 203 | 3 | 0 | 0 | 0 | 18 | 4 | 5 | 3.62 |
| CL | Doolittle, S.Doolittle, Sean † $ >> | 31 | 2018 | L | 98 | 51 | 0 | 4 | 2 | 2.22 | .279 | 1.12 | 7.1 | 3.1 | 9.7 | 52.2 | 41 | 14 | 13 | 1 | 18 | 56 | 0 | 30 | 5 | 0 | 0 | 2 | 0 | 2.25 |
| RP | Soriano, R.Soriano, Rafael >> | 24 | 2003 | R | 83 | 63 | 0 | 10 | 5 | 3.54 | .298 | 1.23 | 7.7 | 3.4 | 8.6 | 76.1 | 65 | 30 | 30 | 8 | 29 | 73 | 0 | 1 | 3 | 0 | 0 | 3 | 0 | 3.71 |
| RP | Rodney, F.Rodney, Fernando >> | 35 | 2012 | R | 80 | 38 | 0 | 1 | 2 | 1.41 | .263 | 1.07 | 7.1 | 2.6 | 10.9 | 38.1 | 30 | 6 | 6 | 3 | 11 | 46 | 0 | 4 | 1 | 0 | 0 | 0 | 3 | 2.47 |
| RP | Gallegos, G.Gallegos, Giovanny >> | 27 | 2019 | R | 78 | 21 | 0 | 1 | 1 | 3.26 | .333 | 1.50 | 10.4 | 3.3 | 8.5 | 19.1 | 22 | 7 | 7 | 1 | 7 | 18 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2.89 |
| RP | Gregerson, L.Gregerson, Luke >> | 26 | 2010 | R | 70 | 17 | 0 | 3 | 2 | 1.96 | .295 | 1.20 | 7.0 | 4.0 | 11.5 | 18.1 | 14 | 4 | 4 | 0 | 8 | 23 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1.94 |