| SP | Scherzer, M.Scherzer, Max >> | 37 | 2021 | R | 97 | 3 | 3 | 1 | 2 | 5.06 | .400 | 2.00 | 11.8 | 6.2 | 8.4 | 16.0 | 21 | 10 | 9 | 1 | 11 | 15 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.00 |
| SP | Martinez, P.Martinez, Pedro >> | 26 | 1997 | R | 90 | 2 | 2 | 1 | 1 | 4.05 | .365 | 1.73 | 11.1 | 4.8 | 7.6 | 13.1 | 16 | 6 | 6 | 0 | 7 | 11 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 2.92 |
| SP | Perez, P.Perez, Pascual >> | 31 | 1988 | R | 85 | 2 | 2 | 1 | 0 | 1.65 | .222 | 0.86 | 6.8 | 1.1 | 5.6 | 16.1 | 12 | 6 | 3 | 1 | 2 | 10 | 1 | 0 | 0 | 0 | 2 | 0 | 1 | 2.94 |
| SP | Roark, T.Roark, Tanner >> | 26 | 2013 | R | 87 | 2 | 2 | 0 | 0 | 1.59 | .261 | 1.06 | 3.6 | 7.2 | 10.8 | 5.2 | 2 | 1 | 1 | 0 | 4 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.00 |
| SP | Strasburg, S.Strasburg, Stephen >> | 28 | 2017 | R | 71 | 2 | 2 | 0 | 1 | 4.82 | .364 | 1.71 | 10.0 | 6.0 | 6.0 | 9.1 | 10 | 7 | 5 | 0 | 6 | 6 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 3.67 |
| RP | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 98 | 6 | 0 | 1 | 0 | 0.90 | .189 | 0.70 | 2.7 | 3.6 | 8.1 | 10.0 | 3 | 1 | 1 | 0 | 4 | 9 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 2.40 |
| RP | Reardon, J.Reardon, Jeff >> | 26 | 1981 | R | 91 | 6 | 0 | 0 | 2 | 2.08 | .278 | 1.15 | 5.6 | 5.6 | 2.3 | 8.2 | 5 | 4 | 2 | 0 | 5 | 2 | 0 | 1 | 2 | 0 | 0 | 0 | 1 | 4.38 |
| RP | Clippard, T.Clippard, Tyler >> | 28 | 2013 | R | 84 | 4 | 0 | 0 | 0 | 0.00 | .160 | 0.57 | 3.9 | 1.3 | 11.6 | 7.0 | 3 | 0 | 0 | 0 | 1 | 9 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.86 |
| RP | Peralta, J.Peralta, Joel >> | 34 | 2010 | R | 83 | 3 | 0 | 1 | 0 | 2.45 | .313 | 1.36 | 6.0 | 9.0 | 9.0 | 3.2 | 2 | 1 | 1 | 0 | 3 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.00 |
| RP | Albers, M.Albers, Matt >> | 34 | 2017 | R | 82 | 1 | 0 | 0 | 0 | 0.00 | .000 | 0.00 | 0.0 | 0.0 | 13.5 | 2.0 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 |
| RP | Hudson, D.Hudson, Daniel >> | 34 | 2021 | R | 68 | 2 | 0 | 0 | 0 | 54.00 | .727 | 7.00 | 63.0 | 0.0 | 27.0 | 1.0 | 7 | 6 | 6 | 0 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0.00 |