| SP | Schmidt, J.Schmidt, Jason >> | 30 | 2003 | R | 99 | 34 | 34 | 16 | 11 | 3.82 | .305 | 1.29 | 9.0 | 2.6 | 8.7 | 219.1 | 218 | 96 | 93 | 23 | 64 | 212 | 6 | 0 | 0 | 4 | 20 | 7 | 7 | 3.40 |
| SP | Pettitte, A.Pettitte, Andy # >> | 33 | 2005 | L | 78 | 33 | 33 | 10 | 15 | 5.35 | .328 | 1.44 | 9.7 | 3.3 | 6.0 | 183.1 | 197 | 115 | 109 | 25 | 67 | 121 | 3 | 0 | 0 | 1 | 13 | 4 | 5 | 4.62 |
| SP | Maddux, G.Maddux, Greg >> | 34 | 2000 | R | 58 | 32 | 32 | 8 | 17 | 6.87 | .359 | 1.62 | 11.8 | 2.8 | 5.8 | 162.1 | 213 | 128 | 124 | 30 | 50 | 105 | 3 | 0 | 0 | 0 | 10 | 10 | 3 | 5.22 |
| SP | Matsuzaka, D.Matsuzaka, Daisuke >> | 28 | 2008 | R | 34 | 32 | 29 | 9 | 6 | 4.05 | .333 | 1.45 | 8.2 | 4.8 | 6.9 | 160.0 | 146 | 77 | 72 | 20 | 86 | 123 | 0 | 0 | 0 | 0 | 12 | 8 | 3 | 4.85 |
| RP | Bailey, A.Bailey, Andrew >> | 25 | 2009 | R | 86 | 76 | 0 | 3 | 5 | 3.95 | .295 | 1.16 | 6.9 | 3.6 | 8.9 | 109.1 | 84 | 55 | 48 | 11 | 43 | 108 | 0 | 6 | 2 | 0 | 0 | 10 | 6 | 3.79 |
| RP | Perez, R.Perez, Rafael >> | 25 | 2007 | L | 65 | 81 | 0 | 4 | 5 | 5.64 | .363 | 1.65 | 10.5 | 4.3 | 9.5 | 99.0 | 116 | 67 | 62 | 14 | 47 | 104 | 0 | 5 | 3 | 0 | 0 | 6 | 4 | 4.34 |
| RP | Otsuka, A.Otsuka, Akinori >> | 32 | 2004 | R | 44 | 63 | 0 | 6 | 3 | 4.43 | .296 | 1.25 | 6.6 | 4.6 | 9.0 | 65.0 | 48 | 34 | 32 | 6 | 33 | 65 | 0 | 3 | 5 | 0 | 0 | 1 | 0 | 3.77 |
| SP | Johnson, J.Johnson, Josh >> | 25 | 2009 | R | 48 | 31 | 5 | 1 | 6 | 8.23 | .354 | 1.60 | 11.6 | 2.8 | 7.2 | 70.0 | 90 | 65 | 64 | 15 | 22 | 56 | 0 | 2 | 1 | 0 | 0 | 3 | 2 | 5.26 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 79 | 46 | 0 | 4 | 3 | 3.54 | .320 | 1.38 | 6.6 | 5.8 | 10.3 | 56.0 | 41 | 24 | 22 | 2 | 36 | 64 | 0 | 0 | 0 | 0 | 0 | 2 | 3 | 3.21 |