| SP | Schmidt, J.Schmidt, Jason >> | 30 | 2003 | R | 99 | 8 | 8 | 4 | 3 | 2.91 | .241 | 0.92 | 6.5 | 1.8 | 10.8 | 55.2 | 40 | 18 | 18 | 5 | 11 | 66 | 3 | 0 | 0 | 3 | 5 | 2 | 1 | 2.49 |
| SP | Pettitte, A.Pettitte, Andy # >> | 33 | 2005 | L | 78 | 8 | 8 | 2 | 5 | 8.00 | .379 | 1.83 | 13.3 | 3.3 | 4.5 | 36.0 | 53 | 32 | 32 | 4 | 13 | 18 | 0 | 0 | 0 | 0 | 2 | 0 | 2 | 4.53 |
| SP | Maddux, G.Maddux, Greg >> | 34 | 2000 | R | 58 | 8 | 8 | 1 | 5 | 6.92 | .366 | 1.66 | 12.2 | 2.9 | 4.7 | 40.1 | 54 | 31 | 31 | 8 | 13 | 21 | 0 | 0 | 0 | 0 | 3 | 3 | 1 | 5.75 |
| SP | Matsuzaka, D.Matsuzaka, Daisuke >> | 28 | 2008 | R | 34 | 8 | 6 | 0 | 2 | 4.11 | .357 | 1.60 | 9.6 | 5.1 | 6.3 | 30.2 | 32 | 16 | 14 | 5 | 17 | 21 | 0 | 0 | 0 | 0 | 1 | 2 | 1 | 5.67 |
| RP | Bailey, A.Bailey, Andrew >> | 25 | 2009 | R | 86 | 20 | 0 | 2 | 0 | 4.50 | .316 | 1.27 | 6.2 | 5.2 | 8.7 | 26.0 | 18 | 16 | 13 | 1 | 15 | 25 | 0 | 1 | 0 | 0 | 0 | 3 | 1 | 3.65 |
| RP | Perez, R.Perez, Rafael >> | 25 | 2007 | L | 65 | 23 | 0 | 0 | 1 | 6.32 | .373 | 1.72 | 10.7 | 4.9 | 6.4 | 31.1 | 37 | 24 | 22 | 6 | 17 | 22 | 0 | 0 | 1 | 0 | 0 | 2 | 2 | 5.94 |
| RP | Otsuka, A.Otsuka, Akinori >> | 32 | 2004 | R | 44 | 21 | 0 | 1 | 1 | 5.23 | .367 | 1.69 | 9.9 | 5.9 | 9.5 | 20.2 | 22 | 12 | 12 | 1 | 13 | 21 | 0 | 0 | 2 | 0 | 0 | 1 | 0 | 3.65 |
| SP | Johnson, J.Johnson, Josh >> | 25 | 2009 | R | 48 | 9 | 5 | 0 | 5 | 9.40 | .373 | 1.72 | 13.3 | 2.5 | 8.4 | 29.2 | 43 | 32 | 31 | 8 | 8 | 27 | 0 | 0 | 1 | 0 | 0 | 2 | 1 | 5.76 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 79 | 12 | 0 | 2 | 0 | 1.84 | .267 | 1.09 | 4.5 | 5.8 | 10.9 | 14.2 | 7 | 3 | 3 | 0 | 9 | 17 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2.50 |