| SP | Harden, R.Harden, Rich † >> | 27 | 2008 | R | 95 | 31 | 31 | 12 | 12 | 2.69 | .268 | 1.08 | 5.5 | 4.2 | 8.5 | 197.1 | 121 | 64 | 59 | 15 | 93 | 187 | 1 | 0 | 0 | 1 | 20 | 3 | 1 | 3.55 |
| SP | Greinke, Z.Greinke, Zack † >> | 26 | 2009 | R | 76 | 30 | 30 | 16 | 8 | 3.84 | .304 | 1.28 | 9.1 | 2.5 | 8.3 | 197.0 | 199 | 88 | 84 | 22 | 54 | 182 | 1 | 0 | 0 | 1 | 19 | 5 | 6 | 3.50 |
| SP | Zambrano, C.Zambrano, Carlos >> | 24 | 2005 | R | 69 | 29 | 29 | 9 | 13 | 6.54 | .382 | 1.85 | 11.0 | 5.7 | 6.5 | 163.2 | 199 | 119 | 119 | 36 | 103 | 118 | 0 | 0 | 0 | 0 | 9 | 1 | 4 | 6.34 |
| SP | Burkett, J.Burkett, John >> | 37 | 2001 | R | 49 | 29 | 28 | 10 | 5 | 4.18 | .307 | 1.31 | 8.6 | 3.2 | 5.7 | 148.2 | 142 | 72 | 69 | 16 | 53 | 93 | 0 | 0 | 0 | 0 | 6 | 3 | 2 | 4.28 |
| SU | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 87 | 43 | 0 | 0 | 4 | 3.28 | .271 | 1.09 | 6.8 | 3.1 | 6.6 | 49.1 | 37 | 18 | 18 | 8 | 17 | 36 | 0 | 6 | 5 | 0 | 0 | 1 | 0 | 4.76 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 79 | 52 | 0 | 3 | 1 | 3.25 | .304 | 1.31 | 7.1 | 4.7 | 10.6 | 61.0 | 48 | 22 | 22 | 7 | 32 | 72 | 0 | 2 | 2 | 0 | 0 | 0 | 3 | 3.70 |
| RP | Wheeler, D.Wheeler, Dan >> | 32 | 2009 | R | 67 | 36 | 0 | 2 | 0 | 3.83 | .283 | 1.14 | 9.0 | 1.4 | 5.7 | 44.2 | 44 | 21 | 19 | 10 | 7 | 28 | 0 | 1 | 1 | 0 | 0 | 2 | 2 | 5.30 |
| SP | Leiter, A.Leiter, Al # >> | 35 | 2000 | L | 41 | 22 | 0 | 5 | 3 | 4.83 | .307 | 1.30 | 8.2 | 3.5 | 7.0 | 82.0 | 75 | 45 | 44 | 13 | 32 | 64 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 4.74 |