| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 100 | 36 | 36 | 21 | 10 | 3.56 | .295 | 1.23 | 8.3 | 2.8 | 8.9 | 245.0 | 227 | 102 | 97 | 35 | 75 | 242 | 4 | 0 | 0 | 2 | 23 | 6 | 6 | 3.87 |
| SP | Vazquez, J.Vazquez, Javier # >> | 33 | 2009 | R | 87 | 34 | 34 | 15 | 8 | 4.55 | .327 | 1.42 | 9.6 | 3.2 | 8.3 | 211.2 | 226 | 110 | 107 | 23 | 74 | 195 | 1 | 0 | 0 | 0 | 17 | 9 | 5 | 3.75 |
| SP | Hernandez, F.Hernandez, Felix † >> | 19 | 2005 | R | 96 | 33 | 33 | 19 | 6 | 4.13 | .301 | 1.27 | 8.3 | 3.1 | 7.2 | 215.2 | 198 | 102 | 99 | 26 | 75 | 172 | 1 | 0 | 0 | 0 | 19 | 5 | 5 | 4.09 |
| SP | Zambrano, C.Zambrano, Carlos >> | 24 | 2005 | R | 71 | 31 | 31 | 13 | 9 | 4.00 | .317 | 1.37 | 7.9 | 4.5 | 7.5 | 191.1 | 167 | 86 | 85 | 25 | 95 | 159 | 1 | 0 | 0 | 1 | 18 | 5 | 6 | 4.61 |
| CL | Gagne, E.Gagne, Eric † >> | 27 | 2003 | R | 100 | 68 | 0 | 5 | 5 | 3.32 | .309 | 1.25 | 7.2 | 4.0 | 10.7 | 65.0 | 52 | 24 | 24 | 3 | 29 | 77 | 0 | 48 | 8 | 0 | 0 | 6 | 5 | 2.85 |
| RP | Rhodes, A.Rhodes, Arthur >> | 32 | 2001 | L | 83 | 85 | 0 | 3 | 1 | 3.54 | .270 | 1.04 | 7.2 | 2.1 | 8.2 | 56.0 | 45 | 22 | 22 | 12 | 13 | 51 | 0 | 2 | 4 | 0 | 0 | 4 | 2 | 4.88 |
| RP | Wuertz, M.Wuertz, Michael >> | 31 | 2009 | R | 71 | 62 | 0 | 1 | 3 | 4.50 | .330 | 1.43 | 8.6 | 4.3 | 9.4 | 42.0 | 40 | 25 | 21 | 5 | 20 | 44 | 0 | 2 | 3 | 0 | 0 | 2 | 4 | 4.02 |
| RP | Mantei, M.Mantei, Matt >> | 30 | 2003 | R | 61 | 38 | 0 | 2 | 0 | 2.79 | .287 | 1.10 | 7.1 | 2.8 | 8.1 | 29.0 | 23 | 10 | 9 | 2 | 9 | 26 | 0 | 3 | 0 | 0 | 0 | 3 | 1 | 3.34 |
| RP | Marte, D.Marte, Damaso >> | 28 | 2003 | L | 55 | 48 | 0 | 3 | 2 | 2.70 | .310 | 1.35 | 7.9 | 4.4 | 9.5 | 33.1 | 29 | 17 | 10 | 2 | 16 | 35 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 3.12 |