| SP | McLain, D.McLain, Denny >> | 24 | 1968 | R | 70 | 8 | 8 | 3 | 3 | 4.17 | .299 | 1.24 | 7.5 | 3.7 | 6.8 | 54.0 | 45 | 25 | 25 | 7 | 22 | 41 | 2 | 0 | 0 | 0 | 5 | 2 | 1 | 4.50 |
| SP | Skubal, T.Skubal, Tarik >> | 28 | 2025 | L | 78 | 7 | 7 | 2 | 3 | 4.10 | .324 | 1.39 | 9.9 | 2.9 | 10.8 | 41.2 | 45 | 21 | 19 | 3 | 13 | 49 | 0 | 0 | 0 | 0 | 4 | 2 | 0 | 2.66 |
| SP | Verlander, J.Verlander, Justin >> | 28 | 2011 | R | 73 | 7 | 7 | 3 | 3 | 5.54 | .329 | 1.45 | 9.0 | 4.1 | 6.8 | 37.1 | 37 | 23 | 23 | 11 | 17 | 28 | 0 | 0 | 0 | 0 | 3 | 1 | 1 | 6.81 |
| SP | Lolich, M.Lolich, Mickey >> | 27 | 1967 | L | 39 | 7 | 7 | 2 | 3 | 3.50 | .344 | 1.55 | 10.2 | 3.9 | 7.8 | 46.1 | 52 | 22 | 18 | 2 | 20 | 40 | 0 | 0 | 0 | 0 | 4 | 1 | 0 | 3.20 |
| SP | Sanchez, A.Sanchez, Anibal >> | 30 | 2014 | R | 36 | 8 | 7 | 3 | 3 | 4.66 | .318 | 1.40 | 10.2 | 2.6 | 6.4 | 38.2 | 43 | 23 | 20 | 11 | 11 | 27 | 0 | 0 | 0 | 0 | 2 | 0 | 1 | 6.21 |
| SU | Holton, T.Holton, Tyler >> | 27 | 2023 | L | 64 | 10 | 0 | 1 | 0 | 4.00 | .341 | 1.56 | 10.0 | 4.0 | 5.0 | 9.0 | 10 | 4 | 4 | 0 | 4 | 5 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.22 |
| CL | Hernandez, W.Hernandez, Willie >> | 30 | 1984 | L | 41 | 13 | 0 | 0 | 3 | 4.41 | .347 | 1.59 | 11.3 | 3.4 | 6.8 | 16.1 | 20 | 8 | 8 | 5 | 6 | 12 | 0 | 4 | 1 | 0 | 0 | 0 | 1 | 6.69 |
| RP | Saucier, K.Saucier, Kevin >> | 25 | 1981 | L | 54 | 21 | 0 | 0 | 1 | 4.60 | .293 | 1.24 | 7.3 | 4.1 | 4.4 | 31.1 | 25 | 17 | 16 | 5 | 14 | 15 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 5.48 |
| RP | Greene, S.Greene, Shane >> | 30 | 2019 | R | 79 | 18 | 0 | 0 | 0 | 3.13 | .250 | 1.00 | 5.5 | 3.5 | 8.6 | 23.0 | 14 | 9 | 8 | 4 | 9 | 22 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 4.52 |
| RP | Melton, T.Melton, Troy >> | 24 | 2025 | R | 36 | 12 | 0 | 1 | 2 | 5.30 | .333 | 1.50 | 7.5 | 6.5 | 7.0 | 18.2 | 15 | 12 | 11 | 2 | 13 | 14 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 5.06 |