| SP | McLain, D.McLain, Denny >> | 24 | 1968 | R | 70 | 34 | 34 | 10 | 14 | 5.25 | .328 | 1.45 | 10.2 | 2.9 | 6.8 | 209.1 | 236 | 126 | 122 | 34 | 67 | 159 | 3 | 0 | 0 | 0 | 15 | 3 | 4 | 4.60 |
| SP | Skubal, T.Skubal, Tarik >> | 28 | 2025 | L | 78 | 33 | 33 | 11 | 14 | 4.51 | .314 | 1.34 | 9.3 | 2.8 | 9.9 | 189.2 | 196 | 102 | 95 | 23 | 58 | 207 | 0 | 0 | 0 | 0 | 17 | 7 | 0 | 3.42 |
| SP | Verlander, J.Verlander, Justin >> | 28 | 2011 | R | 73 | 32 | 32 | 11 | 10 | 4.87 | .316 | 1.36 | 8.6 | 3.6 | 6.8 | 194.0 | 186 | 107 | 105 | 35 | 77 | 147 | 3 | 0 | 0 | 2 | 15 | 6 | 5 | 5.11 |
| SP | Lolich, M.Lolich, Mickey >> | 27 | 1967 | L | 39 | 32 | 32 | 10 | 15 | 4.66 | .347 | 1.57 | 10.0 | 4.1 | 7.0 | 183.1 | 204 | 103 | 95 | 19 | 83 | 142 | 0 | 0 | 0 | 0 | 15 | 5 | 2 | 4.24 |
| SP | Sanchez, A.Sanchez, Anibal >> | 30 | 2014 | R | 36 | 34 | 31 | 13 | 11 | 4.69 | .331 | 1.46 | 10.1 | 3.0 | 6.8 | 161.1 | 181 | 89 | 84 | 27 | 54 | 121 | 0 | 0 | 0 | 0 | 12 | 4 | 4 | 4.76 |
| SU | Holton, T.Holton, Tyler >> | 27 | 2023 | L | 64 | 60 | 0 | 4 | 1 | 3.82 | .300 | 1.25 | 8.4 | 2.8 | 6.0 | 73.0 | 68 | 31 | 31 | 11 | 23 | 49 | 0 | 7 | 3 | 0 | 0 | 3 | 3 | 4.68 |
| CL | Hernandez, W.Hernandez, Willie >> | 30 | 1984 | L | 41 | 67 | 0 | 4 | 9 | 3.72 | .320 | 1.37 | 9.0 | 3.3 | 6.2 | 87.0 | 87 | 36 | 36 | 10 | 32 | 60 | 0 | 28 | 6 | 0 | 0 | 4 | 4 | 4.36 |
| RP | Saucier, K.Saucier, Kevin >> | 25 | 1981 | L | 54 | 90 | 0 | 4 | 2 | 3.38 | .281 | 1.17 | 6.0 | 4.5 | 5.1 | 130.1 | 87 | 52 | 49 | 9 | 65 | 73 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 4.30 |
| RP | Greene, S.Greene, Shane >> | 30 | 2019 | R | 79 | 85 | 0 | 6 | 1 | 3.83 | .305 | 1.30 | 7.9 | 3.9 | 9.3 | 98.2 | 86 | 44 | 42 | 9 | 42 | 101 | 0 | 2 | 1 | 0 | 0 | 2 | 0 | 3.48 |
| RP | Melton, T.Melton, Troy >> | 24 | 2025 | R | 36 | 62 | 0 | 6 | 2 | 2.52 | .297 | 1.26 | 7.2 | 4.1 | 6.7 | 107.1 | 86 | 33 | 30 | 9 | 49 | 80 | 0 | 3 | 0 | 0 | 0 | 1 | 3 | 4.00 |