| SP | Lamet, D.Lamet, Dinelson >> | 27 | 2020 | R | 100 | 36 | 36 | 0 | 5 | 2.64 | .289 | 1.20 | 6.8 | 4.1 | 8.8 | 126.1 | 95 | 42 | 37 | 7 | 57 | 123 | 0 | 0 | 0 | 0 | 0 | 2 | 1 | 3.17 |
| SP | Luebke, C.Luebke, Cory # >> | 26 | 2011 | L | 68 | 23 | 22 | 2 | 3 | 5.03 | .338 | 1.52 | 10.0 | 3.8 | 8.3 | 62.2 | 69 | 37 | 35 | 8 | 26 | 57 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 4.15 |
| SP | Wilson, S.Wilson, Steven >> | 27 | 2022 | R | 78 | 47 | 43 | 1 | 5 | 5.73 | .357 | 1.64 | 10.3 | 4.7 | 7.3 | 48.2 | 55 | 32 | 31 | 9 | 25 | 39 | 0 | 0 | 0 | 0 | 0 | 1 | 4 | 5.44 |
| SP | Darvish, Y.Darvish, Yu >> | 34 | 2021 | R | 57 | 39 | 28 | 5 | 8 | 6.44 | .377 | 1.78 | 11.3 | 4.7 | 8.6 | 124.1 | 156 | 93 | 89 | 17 | 65 | 119 | 0 | 5 | 1 | 0 | 5 | 5 | 13 | 4.56 |
| CL | Benoit, J.Benoit, Joaquin >> | 37 | 2014 | R | 91 | 88 | 0 | 20 | 2 | 1.89 | .271 | 1.05 | 6.0 | 3.4 | 9.0 | 124.0 | 83 | 35 | 26 | 7 | 47 | 124 | 0 | 1 | 1 | 0 | 0 | 8 | 4 | 3.06 |
| SU | Adams, M.Adams, Mike † >> | 31 | 2009 | R | 100 | 91 | 0 | 8 | 3 | 2.14 | .241 | 0.93 | 5.8 | 2.6 | 8.9 | 101.0 | 65 | 24 | 24 | 5 | 29 | 100 | 0 | 30 | 3 | 0 | 0 | 2 | 1 | 2.58 |
| RP | Thatcher, J.Thatcher, Joe >> | 29 | 2010 | L | 69 | 97 | 0 | 7 | 4 | 2.44 | .262 | 1.05 | 7.2 | 2.4 | 8.5 | 99.2 | 79 | 31 | 27 | 9 | 26 | 93 | 0 | 12 | 2 | 0 | 0 | 1 | 0 | 3.12 |
| RP | Strahm, M.Strahm, Matt >> | 26 | 2018 | L | 59 | 99 | 0 | 10 | 5 | 2.87 | .273 | 1.11 | 6.6 | 3.4 | 8.4 | 141.0 | 103 | 54 | 45 | 19 | 53 | 132 | 0 | 0 | 2 | 0 | 0 | 3 | 3 | 4.07 |
| RP | Gregerson, L.Gregerson, Luke >> | 26 | 2010 | R | 80 | 100 | 0 | 14 | 1 | 3.02 | .274 | 1.11 | 6.7 | 3.3 | 8.9 | 125.1 | 93 | 46 | 42 | 12 | 46 | 123 | 0 | 2 | 3 | 0 | 0 | 3 | 0 | 3.46 |
| RP | Hoffman, T.Hoffman, Trevor # >> | 29 | 1996 | R | 75 | 98 | 0 | 8 | 3 | 3.20 | .292 | 1.20 | 7.3 | 3.5 | 10.3 | 121.0 | 98 | 46 | 43 | 11 | 47 | 138 | 0 | 1 | 4 | 0 | 0 | 5 | 2 | 3.19 |
| RP | Street, H.Street, Huston >> | 29 | 2012 | R | 99 | 90 | 0 | 7 | 4 | 4.25 | .290 | 1.21 | 7.0 | 3.8 | 8.9 | 110.0 | 86 | 57 | 52 | 8 | 47 | 109 | 0 | 2 | 3 | 0 | 0 | 2 | 3 | 3.30 |
| RP | Castillo, J.Castillo, Jose >> | 22 | 2018 | L | 67 | 92 | 0 | 12 | 6 | 3.74 | .310 | 1.34 | 7.6 | 4.5 | 9.5 | 108.1 | 91 | 51 | 45 | 6 | 54 | 114 | 0 | 0 | 5 | 0 | 0 | 1 | 1 | 3.14 |