| SP | Skubal, T.Skubal, Tarik # >> | 28 | 2025 | L | 89 | 9 | 9 | 5 | 3 | 3.71 | .260 | 1.01 | 6.6 | 2.6 | 11.3 | 60.2 | 44 | 25 | 25 | 5 | 17 | 75 | 0 | 0 | 0 | 0 | 6 | 3 | 2 | 2.58 |
| SP | Turnbull, S.Turnbull, Spencer >> | 28 | 2021 | R | 46 | 9 | 9 | 0 | 0 | 3.12 | .257 | 1.00 | 4.8 | 4.2 | 6.6 | 26.0 | 14 | 9 | 9 | 2 | 12 | 19 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 4.04 |
| SP | Flaherty, J.Flaherty, Jack >> | 28 | 2024 | R | 53 | 8 | 8 | 2 | 2 | 4.98 | .288 | 1.19 | 8.2 | 2.5 | 9.6 | 47.0 | 43 | 26 | 26 | 9 | 13 | 50 | 0 | 0 | 0 | 0 | 4 | 1 | 0 | 4.26 |
| SP | Melton, T.Melton, Troy >> | 24 | 2025 | R | 49 | 8 | 8 | 0 | 2 | 4.85 | .333 | 1.46 | 8.3 | 4.8 | 4.5 | 26.0 | 24 | 16 | 14 | 1 | 14 | 13 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 4.23 |
| SP | Lolich, M.Lolich, Mickey >> | 28 | 1968 | L | 31 | 9 | 8 | 6 | 1 | 5.96 | .322 | 1.41 | 10.1 | 2.6 | 6.0 | 48.1 | 54 | 32 | 32 | 10 | 14 | 32 | 0 | 0 | 0 | 0 | 2 | 1 | 1 | 5.31 |
| RP | Greene, S.Greene, Shane >> | 30 | 2019 | R | 74 | 24 | 0 | 3 | 1 | 3.30 | .297 | 1.23 | 6.0 | 5.1 | 8.4 | 30.0 | 20 | 11 | 11 | 1 | 17 | 28 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 3.37 |
| RP | Wilson, J.Wilson, Justin >> | 29 | 2017 | L | 67 | 25 | 0 | 2 | 0 | 2.03 | .273 | 1.13 | 5.9 | 4.5 | 11.1 | 26.2 | 17 | 6 | 6 | 1 | 13 | 32 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 2.54 |
| RP | McMahon, D.McMahon, Don >> | 38 | 1968 | R | 56 | 28 | 0 | 2 | 0 | 1.57 | .252 | 1.01 | 6.4 | 2.9 | 8.0 | 28.2 | 20 | 5 | 5 | 0 | 9 | 25 | 0 | 3 | 0 | 0 | 0 | 0 | 2 | 2.18 |
| RP | Rondon, B.Rondon, Bruce >> | 25 | 2016 | R | 54 | 16 | 0 | 1 | 0 | 3.63 | .307 | 1.27 | 7.9 | 3.7 | 9.5 | 17.1 | 15 | 7 | 7 | 0 | 7 | 18 | 0 | 3 | 0 | 0 | 0 | 1 | 1 | 2.29 |
| RP | Walker, J.Walker, Jamie >> | 31 | 2002 | L | 47 | 22 | 0 | 1 | 1 | 1.89 | .296 | 1.26 | 7.6 | 3.8 | 7.1 | 19.0 | 16 | 4 | 4 | 0 | 8 | 15 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 2.68 |
| RP | Miller, S.Miller, Shelby >> | 33 | 2024 | R | 42 | 14 | 0 | 1 | 2 | 3.05 | .253 | 1.02 | 6.3 | 3.2 | 8.6 | 20.2 | 14 | 10 | 7 | 2 | 7 | 19 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.45 |
| SP | Holton, T.Holton, Tyler >> | 28 | 2024 | L | 98 | 18 | 0 | 7 | 0 | 3.60 | .313 | 1.33 | 9.3 | 2.7 | 4.5 | 30.0 | 31 | 12 | 12 | 3 | 9 | 15 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 4.30 |