| SP | Darvish, Y.Darvish, Yu >> | 34 | 2021 | R | 60 | 36 | 34 | 14 | 12 | 3.54 | .304 | 1.31 | 9.0 | 2.8 | 8.1 | 201.0 | 201 | 90 | 79 | 19 | 62 | 181 | 0 | 0 | 0 | 0 | 19 | 1 | 3 | 3.37 |
| SP | Lamet, D.Lamet, Dinelson # >> | 27 | 2020 | R | 98 | 35 | 30 | 0 | 3 | 4.90 | .284 | 1.18 | 8.3 | 2.3 | 10.5 | 68.0 | 63 | 38 | 37 | 7 | 17 | 79 | 0 | 0 | 0 | 0 | 0 | 1 | 4 | 2.81 |
| SP | Wilson, S.Wilson, Steven >> | 27 | 2022 | R | 75 | 44 | 37 | 0 | 4 | 4.88 | .338 | 1.51 | 8.8 | 4.9 | 9.2 | 51.2 | 50 | 28 | 28 | 5 | 28 | 52 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 3.94 |
| CL | Adams, M.Adams, Mike † >> | 31 | 2009 | R | 99 | 83 | 0 | 10 | 5 | 2.78 | .267 | 1.08 | 6.2 | 3.5 | 9.1 | 97.0 | 67 | 35 | 30 | 3 | 38 | 98 | 0 | 19 | 5 | 0 | 0 | 1 | 1 | 2.59 |
| RP | Street, H.Street, Huston >> | 29 | 2012 | R | 97 | 91 | 0 | 4 | 1 | 3.19 | .292 | 1.23 | 7.0 | 4.1 | 9.5 | 113.0 | 88 | 44 | 40 | 9 | 51 | 119 | 0 | 4 | 6 | 0 | 0 | 1 | 6 | 3.31 |
| RP | Hoffman, T.Hoffman, Trevor >> | 29 | 1996 | R | 66 | 88 | 0 | 5 | 2 | 3.00 | .308 | 1.31 | 7.6 | 4.2 | 9.2 | 102.0 | 86 | 39 | 34 | 6 | 48 | 104 | 0 | 8 | 3 | 0 | 0 | 2 | 5 | 3.20 |
| RP | Thatcher, J.Thatcher, Joe † >> | 29 | 2010 | L | 62 | 97 | 0 | 14 | 4 | 3.51 | .295 | 1.24 | 8.2 | 3.1 | 8.3 | 107.2 | 97 | 43 | 42 | 13 | 37 | 99 | 0 | 5 | 1 | 0 | 0 | 1 | 0 | 3.79 |
| RP | Benoit, J.Benoit, Joaquin >> | 37 | 2014 | R | 84 | 91 | 0 | 6 | 3 | 3.41 | .294 | 1.22 | 7.2 | 3.8 | 9.7 | 97.2 | 78 | 41 | 37 | 12 | 41 | 105 | 0 | 2 | 3 | 0 | 0 | 3 | 6 | 3.80 |
| RP | Strahm, M.Strahm, Matt >> | 26 | 2018 | L | 49 | 99 | 0 | 11 | 5 | 4.19 | .307 | 1.31 | 7.8 | 4.1 | 9.3 | 124.2 | 107 | 65 | 58 | 12 | 56 | 128 | 0 | 2 | 8 | 0 | 0 | 3 | 2 | 3.62 |
| RP | Gregerson, L.Gregerson, Luke >> | 26 | 2010 | R | 72 | 84 | 0 | 5 | 4 | 4.62 | .306 | 1.29 | 8.9 | 2.8 | 8.5 | 87.2 | 86 | 48 | 45 | 9 | 27 | 82 | 0 | 1 | 2 | 0 | 0 | 3 | 0 | 3.49 |
| RP | Castillo, J.Castillo, Jose >> | 22 | 2018 | L | 60 | 92 | 0 | 10 | 3 | 4.53 | .324 | 1.43 | 8.4 | 4.5 | 8.9 | 97.1 | 91 | 55 | 49 | 12 | 48 | 96 | 0 | 3 | 7 | 0 | 0 | 1 | 2 | 4.14 |