| SP | Arrieta, J.Arrieta, Jake † # >> | 29 | 2015 | R | 93 | 36 | 36 | 16 | 12 | 3.93 | .296 | 1.24 | 8.6 | 2.5 | 8.3 | 252.0 | 241 | 116 | 110 | 22 | 71 | 231 | 5 | 0 | 0 | 1 | 21 | 6 | 4 | 3.22 |
| SP | Brown, M.Brown, Mordecai † >> | 32 | 1908 | R | 90 | 35 | 35 | 20 | 8 | 3.21 | .284 | 1.18 | 8.3 | 2.3 | 4.8 | 271.2 | 251 | 99 | 97 | 19 | 69 | 146 | 5 | 0 | 0 | 1 | 23 | 4 | 2 | 3.64 |
| SP | Pfiester, J.Pfiester, Jack >> | 28 | 1906 | L | 70 | 34 | 34 | 12 | 16 | 4.38 | .308 | 1.32 | 8.6 | 3.2 | 5.3 | 246.1 | 236 | 122 | 120 | 24 | 88 | 144 | 11 | 0 | 0 | 1 | 14 | 5 | 2 | 4.23 |
| SP | Wesneski, H.Wesneski, Hayden >> | 24 | 2022 | R | 68 | 33 | 33 | 1 | 4 | 2.83 | .282 | 1.17 | 7.5 | 3.0 | 8.0 | 89.0 | 74 | 31 | 28 | 4 | 30 | 79 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 2.85 |
| SP | Alexander, P.Alexander, Pete >> | 32 | 1919 | R | 60 | 31 | 30 | 12 | 7 | 4.60 | .320 | 1.39 | 9.6 | 2.8 | 4.9 | 223.0 | 239 | 123 | 114 | 34 | 70 | 122 | 9 | 0 | 0 | 1 | 14 | 6 | 3 | 4.91 |
| RP | Kimbrel, C.Kimbrel, Craig † >> | 33 | 2021 | R | 97 | 91 | 0 | 16 | 4 | 3.14 | .313 | 1.35 | 6.4 | 5.8 | 11.1 | 109.0 | 77 | 39 | 38 | 4 | 70 | 134 | 0 | 10 | 4 | 0 | 0 | 2 | 5 | 3.00 |
| RP | Edwards, C.Edwards, Carl † >> | 24 | 2016 | R | 91 | 75 | 0 | 7 | 2 | 2.09 | .232 | 0.90 | 5.0 | 3.2 | 8.2 | 94.2 | 52 | 23 | 22 | 3 | 33 | 86 | 0 | 13 | 2 | 0 | 0 | 1 | 8 | 2.67 |
| RP | Tepera, R.Tepera, Ryan >> | 33 | 2021 | R | 87 | 51 | 0 | 4 | 4 | 3.42 | .293 | 1.21 | 7.4 | 3.6 | 8.3 | 68.1 | 56 | 27 | 26 | 5 | 27 | 63 | 0 | 3 | 2 | 0 | 0 | 2 | 4 | 3.38 |
| RP | Hodge, P.Hodge, Porter >> | 23 | 2024 | R | 80 | 48 | 0 | 1 | 3 | 4.60 | .308 | 1.32 | 6.9 | 5.1 | 7.2 | 60.2 | 46 | 32 | 31 | 4 | 34 | 48 | 0 | 6 | 2 | 0 | 0 | 1 | 2 | 4.02 |
| RP | Miller, T.Miller, Tyson >> | 28 | 2024 | R | 66 | 31 | 0 | 7 | 1 | 2.72 | .275 | 1.07 | 5.2 | 4.4 | 6.1 | 43.0 | 25 | 17 | 13 | 3 | 21 | 29 | 0 | 2 | 1 | 0 | 0 | 3 | 0 | 4.23 |
| RP | Rondon, H.Rondon, Hector >> | 28 | 2016 | R | 44 | 29 | 0 | 2 | 3 | 5.19 | .381 | 1.81 | 11.4 | 4.8 | 8.7 | 26.0 | 33 | 15 | 15 | 2 | 14 | 25 | 0 | 3 | 0 | 0 | 0 | 1 | 1 | 3.81 |