| SP | Martinez, P.Martinez, Pedro >> | 30 | 2001 | R | 76 | 9 | 9 | 2 | 6 | 5.45 | .364 | 1.69 | 12.7 | 2.8 | 10.6 | 39.2 | 55 | 28 | 24 | 6 | 12 | 46 | 0 | 0 | 0 | 0 | 4 | 1 | 3 | 3.64 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 90 | 23 | 0 | 2 | 1 | 1.71 | .208 | 0.79 | 5.2 | 2.0 | 9.3 | 31.2 | 18 | 11 | 6 | 2 | 7 | 32 | 0 | 1 | 2 | 0 | 0 | 0 | 0 | 2.45 |
| RP | Workman, B.Workman, Brandon >> | 30 | 2019 | R | 62 | 22 | 0 | 5 | 1 | 2.93 | .320 | 1.41 | 6.7 | 6.3 | 10.7 | 27.2 | 20 | 9 | 9 | 0 | 19 | 32 | 0 | 0 | 3 | 0 | 0 | 0 | 0 | 2.74 |
| RP | Chapman, A.Chapman, Aroldis >> | 37 | 2025 | L | 95 | 26 | 0 | 1 | 0 | 3.86 | .238 | 0.94 | 5.4 | 3.2 | 8.6 | 25.2 | 15 | 11 | 11 | 3 | 9 | 24 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 3.72 |
| RP | Brasier, R.Brasier, Ryan >> | 30 | 2018 | R | 78 | 22 | 0 | 5 | 2 | 3.64 | .305 | 1.28 | 7.1 | 4.7 | 7.8 | 29.2 | 23 | 12 | 12 | 2 | 15 | 25 | 0 | 3 | 0 | 0 | 0 | 1 | 3 | 3.83 |
| RP | Uehara, K.Uehara, Koji >> | 38 | 2013 | R | 99 | 22 | 0 | 0 | 1 | 1.93 | .236 | 0.93 | 6.1 | 2.3 | 11.3 | 28.0 | 19 | 6 | 6 | 4 | 7 | 35 | 0 | 6 | 0 | 0 | 0 | 0 | 0 | 3.11 |
| RP | Kimbrel, C.Kimbrel, Craig >> | 29 | 2017 | R | 98 | 15 | 0 | 0 | 2 | 3.38 | .273 | 1.13 | 9.0 | 1.5 | 11.5 | 18.2 | 18 | 7 | 7 | 2 | 3 | 23 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 2.39 |
| RP | O'Brien, B.O'Brien, Buck >> | 29 | 1911 | R | 40 | 10 | 0 | 0 | 0 | 2.08 | .250 | 1.00 | 5.5 | 3.5 | 4.2 | 13.0 | 8 | 3 | 3 | 1 | 5 | 6 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 4.23 |