| SP | Steele, E.Steele, Elmer >> | 22 | 1908 | R | 84 | 35 | 35 | 18 | 10 | 3.80 | .301 | 1.28 | 8.9 | 2.6 | 4.7 | 217.2 | 215 | 96 | 92 | 9 | 63 | 114 | 4 | 0 | 0 | 1 | 20 | 3 | 0 | 3.40 |
| SP | Martinez, P.Martinez, Pedro >> | 30 | 2001 | R | 88 | 34 | 34 | 16 | 10 | 4.16 | .300 | 1.27 | 8.2 | 3.2 | 9.0 | 186.0 | 170 | 88 | 86 | 20 | 66 | 185 | 1 | 0 | 0 | 1 | 13 | 3 | 5 | 3.52 |
| SP | Shore, E.Shore, Ernie # >> | 23 | 1914 | R | 69 | 32 | 32 | 16 | 5 | 3.64 | .279 | 1.16 | 8.3 | 2.2 | 4.5 | 185.2 | 170 | 79 | 75 | 17 | 45 | 93 | 3 | 0 | 0 | 2 | 19 | 1 | 4 | 3.94 |
| SP | Cicotte, E.Cicotte, Eddie >> | 25 | 1909 | R | 62 | 31 | 31 | 13 | 5 | 3.58 | .291 | 1.20 | 7.4 | 3.5 | 4.1 | 161.0 | 132 | 65 | 64 | 15 | 62 | 74 | 0 | 0 | 0 | 0 | 8 | 4 | 1 | 4.52 |
| RP | Uehara, K.Uehara, Koji >> | 38 | 2013 | R | 100 | 84 | 0 | 10 | 2 | 3.44 | .274 | 1.09 | 7.5 | 2.3 | 8.9 | 123.0 | 103 | 48 | 47 | 15 | 31 | 121 | 0 | 2 | 5 | 0 | 0 | 5 | 2 | 3.50 |
| RP | Brasier, R.Brasier, Ryan † >> | 30 | 2018 | R | 78 | 82 | 0 | 13 | 3 | 2.35 | .257 | 1.04 | 5.9 | 3.4 | 5.9 | 118.2 | 78 | 32 | 31 | 9 | 45 | 77 | 0 | 7 | 2 | 0 | 0 | 0 | 2 | 3.83 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 94 | 73 | 0 | 5 | 4 | 2.72 | .258 | 1.02 | 6.5 | 2.7 | 9.9 | 96.0 | 69 | 31 | 29 | 7 | 29 | 106 | 0 | 11 | 3 | 0 | 0 | 2 | 0 | 2.71 |
| RP | Miller, A.Miller, Andrew >> | 29 | 2014 | L | 74 | 60 | 0 | 3 | 2 | 3.77 | .297 | 1.26 | 7.5 | 3.8 | 8.8 | 74.0 | 62 | 31 | 31 | 6 | 31 | 72 | 0 | 4 | 3 | 0 | 0 | 1 | 7 | 3.41 |
| RP | Young, D.Young, Danny # >> | 30 | 2024 | L | 29 | 39 | 0 | 1 | 3 | 5.56 | .367 | 1.74 | 9.8 | 6.1 | 10.3 | 43.2 | 47 | 27 | 27 | 6 | 29 | 49 | 0 | 4 | 4 | 0 | 0 | 0 | 3 | 4.56 |
| SP | Gullickson, B.Gullickson, Bill >> | 28 | 1987 | R | 35 | 9 | 0 | 0 | 2 | 8.76 | .373 | 1.78 | 13.5 | 3.0 | 5.3 | 12.1 | 18 | 12 | 12 | 7 | 4 | 7 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 10.42 |