| SP | Skubal, T.Skubal, Tarik >> | 28 | 2025 | L | 100 | 25 | 25 | 8 | 8 | 3.45 | .293 | 1.21 | 8.5 | 2.4 | 9.6 | 172.1 | 162 | 67 | 66 | 14 | 46 | 184 | 1 | 0 | 0 | 1 | 15 | 6 | 3 | 2.83 |
| SP | Brown, H.Brown, Hunter † >> | 26 | 2025 | R | 93 | 24 | 24 | 12 | 4 | 3.08 | .299 | 1.23 | 7.7 | 3.4 | 11.0 | 158.0 | 136 | 58 | 54 | 15 | 59 | 193 | 1 | 0 | 0 | 1 | 18 | 7 | 0 | 3.04 |
| SP | Nelson, R.Nelson, Ryne >> | 27 | 2025 | R | 81 | 24 | 23 | 6 | 8 | 6.02 | .371 | 1.70 | 11.8 | 3.7 | 8.1 | 101.2 | 132 | 73 | 68 | 17 | 41 | 91 | 0 | 0 | 0 | 0 | 1 | 7 | 1 | 4.81 |
| RP | Svanson, M.Svanson, Matt † >> | 26 | 2025 | R | 98 | 81 | 0 | 6 | 2 | 3.27 | .285 | 1.17 | 7.0 | 3.5 | 10.4 | 132.0 | 103 | 49 | 48 | 15 | 51 | 153 | 0 | 6 | 6 | 0 | 0 | 4 | 1 | 3.41 |
| RP | Iglesias, R.Iglesias, Raisel >> | 35 | 2025 | R | 78 | 60 | 0 | 5 | 1 | 4.14 | .315 | 1.34 | 10.1 | 2.0 | 11.8 | 71.2 | 80 | 34 | 33 | 13 | 16 | 93 | 0 | 5 | 3 | 0 | 0 | 3 | 0 | 3.56 |
| RP | Rodríguez, Y.Rodríguez, Yariel >> | 28 | 2025 | R | 67 | 49 | 0 | 3 | 3 | 4.11 | .355 | 1.61 | 10.1 | 4.4 | 8.4 | 57.0 | 64 | 27 | 26 | 5 | 28 | 53 | 0 | 7 | 2 | 0 | 0 | 2 | 3 | 3.86 |