| SP | Newhouser, H.Newhouser, Hal >> | 23 | 1944 | L | 86 | 16 | 16 | 4 | 9 | 6.34 | .347 | 1.57 | 10.5 | 3.6 | 3.7 | 88.0 | 103 | 71 | 62 | 11 | 35 | 36 | 0 | 0 | 0 | 0 | 5 | 2 | 2 | 5.07 |
| SP | Mitchell, W.Mitchell, Willie >> | 28 | 1917 | L | 76 | 16 | 16 | 3 | 8 | 7.46 | .380 | 1.82 | 12.6 | 3.7 | 4.2 | 82.0 | 115 | 72 | 68 | 11 | 34 | 38 | 0 | 0 | 0 | 0 | 3 | 2 | 0 | 5.13 |
| SP | Vuckovich, P.Vuckovich, Pete >> | 26 | 1978 | R | 65 | 16 | 16 | 2 | 2 | 4.82 | .345 | 1.58 | 11.3 | 3.0 | 4.6 | 74.2 | 93 | 40 | 40 | 3 | 25 | 38 | 0 | 0 | 0 | 0 | 1 | 0 | 4 | 3.51 |
| SP | Lyles, J.Lyles, Jordan >> | 32 | 2023 | R | 52 | 15 | 15 | 7 | 4 | 5.40 | .331 | 1.47 | 9.3 | 3.9 | 6.5 | 85.0 | 88 | 53 | 51 | 7 | 37 | 61 | 0 | 0 | 0 | 0 | 5 | 1 | 5 | 3.98 |
| RP | Eastwick, R.Eastwick, Rawly >> | 25 | 1975 | R | 75 | 44 | 0 | 8 | 2 | 4.50 | .304 | 1.28 | 8.1 | 3.4 | 5.3 | 68.0 | 61 | 45 | 34 | 9 | 26 | 40 | 0 | 1 | 2 | 0 | 0 | 2 | 0 | 4.78 |
| RP | Garcia, J.Garcia, Jarlin >> | 29 | 2022 | L | 63 | 36 | 0 | 4 | 1 | 2.34 | .314 | 1.37 | 8.8 | 3.6 | 7.1 | 42.1 | 41 | 12 | 11 | 2 | 17 | 33 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 3.26 |
| CL | Jansen, K.Jansen, Kenley >> | 25 | 2013 | R | 99 | 32 | 0 | 0 | 3 | 3.16 | .282 | 1.15 | 7.8 | 2.6 | 10.7 | 31.1 | 27 | 12 | 11 | 3 | 9 | 37 | 0 | 20 | 3 | 0 | 0 | 1 | 1 | 2.84 |
| SU | Valverde, J.Valverde, Jose >> | 31 | 2010 | R | 85 | 37 | 0 | 3 | 1 | 2.33 | .329 | 1.42 | 7.3 | 5.7 | 6.6 | 38.2 | 31 | 15 | 10 | 1 | 24 | 28 | 0 | 1 | 1 | 0 | 0 | 2 | 1 | 3.92 |