| SP | Kershaw, C.Kershaw, Clayton >> | 28 | 2016 | L | 99 | 10 | 10 | 4 | 3 | 3.00 | .267 | 1.08 | 7.8 | 1.9 | 8.4 | 75.0 | 65 | 25 | 25 | 6 | 16 | 70 | 2 | 0 | 0 | 1 | 8 | 1 | 1 | 2.85 |
| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 93 | 10 | 10 | 5 | 5 | 3.19 | .275 | 1.14 | 7.3 | 3.0 | 7.6 | 79.0 | 64 | 30 | 28 | 4 | 26 | 67 | 4 | 0 | 0 | 0 | 7 | 0 | 0 | 2.95 |
| CL | Kimbrel, C.Kimbrel, Craig >> | 24 | 2012 | R | 100 | 18 | 0 | 1 | 3 | 2.61 | .295 | 1.21 | 8.6 | 2.7 | 9.5 | 20.2 | 19 | 7 | 6 | 1 | 6 | 21 | 0 | 10 | 2 | 0 | 0 | 1 | 0 | 2.60 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 93 | 22 | 0 | 0 | 0 | 2.12 | .190 | 0.71 | 3.7 | 2.6 | 11.1 | 17.0 | 7 | 4 | 4 | 2 | 5 | 21 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2.94 |
| RP | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 88 | 6 | 0 | 0 | 0 | 1.69 | .360 | 1.31 | 9.0 | 3.6 | 7.2 | 5.1 | 5 | 1 | 1 | 0 | 2 | 4 | 0 | 1 | 0 | 0 | 0 | 2 | 0 | 3.80 |
| RP | Devine, J.Devine, Joey >> | 25 | 2008 | R | 81 | 3 | 0 | 2 | 0 | 0.00 | .100 | 0.33 | 0.0 | 3.0 | 15.0 | 3.0 | 0 | 0 | 0 | 0 | 1 | 5 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.67 |
| SP | Darvish, Y.Darvish, Yu >> | 35 | 2022 | R | 64 | 2 | 0 | 0 | 0 | 2.57 | .250 | 1.00 | 6.4 | 2.6 | 7.7 | 7.0 | 5 | 2 | 2 | 2 | 2 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 5.86 |