| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 28 | 28 | 7 | 11 | 3.26 | .281 | 1.16 | 7.6 | 2.9 | 9.1 | 176.2 | 149 | 70 | 64 | 9 | 56 | 178 | 0 | 0 | 0 | 0 | 20 | 2 | 0 | 2.63 |
| SP | Nelson, R.Nelson, Roger >> | 28 | 1972 | R | 85 | 27 | 27 | 5 | 11 | 5.92 | .332 | 1.49 | 9.8 | 3.6 | 4.4 | 132.1 | 144 | 94 | 87 | 22 | 53 | 64 | 0 | 0 | 0 | 0 | 8 | 0 | 4 | 5.40 |
| SP | McLain, D.McLain, Denny >> | 24 | 1968 | R | 79 | 27 | 27 | 11 | 16 | 3.95 | .325 | 1.43 | 9.3 | 3.5 | 6.1 | 196.0 | 203 | 92 | 86 | 16 | 77 | 132 | 8 | 0 | 0 | 1 | 15 | 3 | 3 | 3.94 |
| SP | Chesbro, J.Chesbro, Jack # >> | 30 | 1904 | R | 65 | 26 | 26 | 8 | 14 | 5.26 | .335 | 1.50 | 10.2 | 3.3 | 4.6 | 171.0 | 194 | 103 | 100 | 24 | 63 | 88 | 9 | 0 | 0 | 1 | 12 | 2 | 0 | 4.94 |
| CL | Uehara, K.Uehara, Koji † >> | 38 | 2013 | R | 100 | 46 | 0 | 3 | 5 | 3.04 | .279 | 1.14 | 6.5 | 3.8 | 7.3 | 47.1 | 34 | 17 | 16 | 2 | 20 | 38 | 0 | 28 | 4 | 0 | 0 | 1 | 0 | 3.28 |
| RP | Saito, T.Saito, Takashi >> | 37 | 2007 | R | 92 | 74 | 0 | 3 | 0 | 5.31 | .324 | 1.43 | 9.4 | 3.5 | 8.8 | 84.2 | 88 | 52 | 50 | 5 | 33 | 82 | 0 | 0 | 3 | 0 | 0 | 1 | 0 | 3.04 |
| RP | Soriano, R.Soriano, Rafael >> | 24 | 2003 | R | 84 | 57 | 0 | 3 | 1 | 4.90 | .306 | 1.29 | 8.5 | 3.2 | 10.1 | 68.0 | 64 | 39 | 37 | 10 | 24 | 76 | 0 | 0 | 1 | 0 | 0 | 2 | 0 | 3.82 |
| RP | Hoffman, T.Hoffman, Trevor >> | 31 | 1998 | R | 75 | 48 | 0 | 2 | 2 | 3.70 | .325 | 1.43 | 8.7 | 4.3 | 8.9 | 65.2 | 63 | 31 | 27 | 9 | 31 | 64 | 0 | 0 | 0 | 0 | 0 | 1 | 6 | 4.31 |
| RP | Sutter, B.Sutter, Bruce >> | 24 | 1977 | R | 68 | 37 | 0 | 3 | 3 | 6.27 | .393 | 1.90 | 12.3 | 5.0 | 7.1 | 47.1 | 64 | 35 | 33 | 9 | 26 | 37 | 0 | 0 | 1 | 0 | 0 | 2 | 3 | 5.70 |