| SP | Koufax, S.Koufax, Sandy † >> | 30 | 1965 | L | 98 | 28 | 28 | 15 | 9 | 2.54 | .240 | 0.94 | 6.4 | 2.0 | 7.3 | 208.2 | 149 | 62 | 59 | 13 | 47 | 169 | 10 | 0 | 0 | 6 | 19 | 2 | 3 | 2.89 |
| SP | Maddux, G.Maddux, Greg † >> | 29 | 1995 | R | 89 | 27 | 27 | 16 | 9 | 3.36 | .259 | 1.03 | 7.3 | 2.0 | 5.0 | 187.1 | 152 | 71 | 70 | 20 | 41 | 103 | 2 | 0 | 0 | 0 | 18 | 3 | 3 | 3.99 |
| SP | Reulbach, E.Reulbach, Ed >> | 24 | 1906 | R | 60 | 27 | 27 | 11 | 6 | 2.85 | .295 | 1.22 | 6.5 | 4.5 | 4.0 | 180.0 | 130 | 61 | 57 | 6 | 89 | 80 | 2 | 0 | 0 | 1 | 22 | 7 | 3 | 4.14 |
| SP | Fernandez, J.Fernandez, Jose >> | 21 | 2013 | R | 76 | 27 | 27 | 13 | 9 | 4.16 | .328 | 1.44 | 9.1 | 3.9 | 7.5 | 158.0 | 160 | 74 | 73 | 18 | 68 | 131 | 0 | 0 | 0 | 0 | 17 | 3 | 0 | 4.17 |
| RP | Eckersley, D.Eckersley, Dennis # >> | 36 | 1990 | R | 88 | 72 | 0 | 4 | 2 | 3.65 | .275 | 1.11 | 8.8 | 1.2 | 7.0 | 88.2 | 86 | 39 | 36 | 6 | 12 | 68 | 0 | 2 | 2 | 0 | 0 | 3 | 0 | 2.85 |
| RP | Capps, C.Capps, Carter # >> | 24 | 2015 | R | 85 | 52 | 0 | 3 | 3 | 6.22 | .360 | 1.69 | 10.1 | 5.1 | 10.5 | 55.0 | 62 | 40 | 38 | 7 | 31 | 64 | 0 | 2 | 1 | 0 | 0 | 0 | 2 | 4.02 |
| RP | Holland, G.Holland, Greg >> | 27 | 2013 | R | 72 | 44 | 0 | 1 | 2 | 3.47 | .307 | 1.33 | 8.2 | 3.9 | 7.2 | 46.2 | 42 | 20 | 18 | 3 | 20 | 37 | 0 | 2 | 2 | 0 | 0 | 0 | 1 | 3.54 |
| RP | Britton, Z.Britton, Zach >> | 28 | 2016 | L | 78 | 34 | 0 | 2 | 0 | 5.50 | .307 | 1.33 | 9.5 | 2.7 | 7.8 | 37.2 | 39 | 25 | 23 | 5 | 11 | 32 | 0 | 0 | 2 | 0 | 0 | 0 | 2 | 3.92 |
| CL | Chapman, A.Chapman, Aroldis † >> | 26 | 2014 | L | 94 | 54 | 0 | 3 | 5 | 1.79 | .249 | 0.96 | 4.5 | 4.2 | 11.0 | 60.1 | 30 | 12 | 12 | 2 | 28 | 73 | 0 | 31 | 2 | 0 | 0 | 2 | 1 | 2.50 |