| SP | Clemens, R.Clemens, Roger >> | 43 | 2005 | R | 94 | 12 | 12 | 2 | 4 | 3.81 | .304 | 1.31 | 8.4 | 3.3 | 6.5 | 78.0 | 73 | 34 | 33 | 11 | 29 | 56 | 0 | 0 | 0 | 0 | 7 | 0 | 0 | 4.51 |
| SP | Zambrano, C.Zambrano, Carlos >> | 24 | 2005 | R | 70 | 11 | 11 | 5 | 4 | 6.23 | .375 | 1.75 | 10.7 | 5.3 | 6.9 | 60.2 | 71 | 43 | 42 | 8 | 35 | 46 | 0 | 0 | 0 | 0 | 5 | 3 | 2 | 5.10 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 26 | 2006 | R | 93 | 29 | 0 | 2 | 1 | 5.03 | .318 | 1.37 | 9.7 | 2.8 | 9.5 | 39.1 | 42 | 22 | 22 | 1 | 12 | 41 | 0 | 4 | 3 | 0 | 0 | 1 | 0 | 2.23 |
| RP | Bailey, A.Bailey, Andrew >> | 25 | 2009 | R | 85 | 26 | 0 | 3 | 3 | 3.45 | .301 | 1.26 | 9.3 | 2.3 | 9.3 | 28.2 | 29 | 11 | 11 | 1 | 7 | 29 | 0 | 4 | 4 | 0 | 0 | 1 | 1 | 2.25 |
| RP | Donnelly, B.Donnelly, Brendan >> | 32 | 2003 | R | 40 | 10 | 0 | 0 | 0 | 0.66 | .163 | 0.51 | 3.5 | 1.4 | 9.7 | 13.2 | 5 | 1 | 1 | 0 | 2 | 14 | 0 | 2 | 0 | 0 | 0 | 1 | 0 | 1.54 |
| SP | Kazmir, S.Kazmir, Scott >> | 24 | 2008 | L | 40 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |