| SP | Schilling, C.Schilling, Curt † # >> | 36 | 2002 | R | 93 | 24 | 24 | 11 | 8 | 3.84 | .295 | 1.25 | 8.5 | 2.7 | 10.4 | 168.2 | 159 | 77 | 72 | 19 | 51 | 195 | 7 | 0 | 0 | 2 | 12 | 2 | 2 | 3.10 |
| SP | Wakefield, T.Wakefield, Tim >> | 36 | 2002 | R | 84 | 24 | 24 | 1 | 5 | 3.74 | .307 | 1.32 | 9.1 | 2.8 | 7.5 | 96.1 | 97 | 43 | 40 | 11 | 30 | 80 | 0 | 0 | 0 | 0 | 0 | 1 | 2 | 3.79 |
| SP | Sabathia, C.Sabathia, CC >> | 28 | 2008 | L | 60 | 23 | 23 | 11 | 8 | 5.70 | .341 | 1.52 | 10.0 | 3.7 | 7.1 | 148.1 | 165 | 98 | 94 | 21 | 61 | 117 | 4 | 0 | 0 | 1 | 9 | 4 | 1 | 4.58 |
| SP | Loaiza, E.Loaiza, Esteban >> | 32 | 2003 | R | 59 | 24 | 22 | 4 | 6 | 5.14 | .330 | 1.46 | 9.8 | 3.3 | 6.8 | 138.1 | 151 | 83 | 79 | 25 | 51 | 104 | 1 | 1 | 0 | 0 | 10 | 2 | 3 | 5.00 |
| CL | Papelbon, J.Papelbon, Jonathan † >> | 26 | 2006 | R | 93 | 49 | 0 | 3 | 5 | 2.97 | .279 | 1.16 | 8.2 | 2.4 | 8.2 | 57.2 | 52 | 19 | 19 | 7 | 15 | 52 | 0 | 20 | 4 | 0 | 0 | 0 | 0 | 3.56 |
| SU | Zimmerman, J.Zimmerman, Jeff >> | 29 | 2001 | R | 75 | 45 | 0 | 3 | 2 | 3.99 | .284 | 1.13 | 9.0 | 1.3 | 10.7 | 49.2 | 49 | 23 | 22 | 7 | 7 | 58 | 0 | 5 | 7 | 0 | 0 | 3 | 0 | 3.10 |
| RP | Isringhausen, J.Isringhausen, Jason >> | 32 | 2004 | R | 38 | 57 | 0 | 11 | 2 | 5.52 | .333 | 1.43 | 9.6 | 3.3 | 7.3 | 73.1 | 78 | 50 | 45 | 18 | 27 | 59 | 0 | 2 | 1 | 0 | 0 | 5 | 3 | 5.90 |
| RP | Rincon, J.Rincon, Juan >> | 25 | 2004 | R | 60 | 52 | 0 | 4 | 1 | 2.57 | .287 | 1.16 | 5.6 | 4.9 | 8.9 | 63.0 | 39 | 18 | 18 | 2 | 34 | 62 | 0 | 0 | 2 | 0 | 0 | 3 | 0 | 3.21 |
| RP | Wheeler, D.Wheeler, Dan >> | 32 | 2009 | R | 67 | 35 | 0 | 4 | 4 | 4.46 | .328 | 1.42 | 10.3 | 2.6 | 5.6 | 42.1 | 48 | 22 | 21 | 6 | 12 | 26 | 0 | 1 | 3 | 0 | 0 | 2 | 3 | 4.62 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 84 | 31 | 0 | 3 | 0 | 4.25 | .315 | 1.38 | 6.8 | 5.9 | 9.6 | 29.2 | 22 | 16 | 14 | 1 | 19 | 31 | 0 | 1 | 0 | 0 | 0 | 0 | 2 | 3.28 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 86 | 32 | 0 | 2 | 0 | 7.15 | .338 | 1.53 | 11.6 | 2.1 | 9.3 | 34.0 | 44 | 28 | 27 | 7 | 8 | 35 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.32 |