| SP | Schilling, C.Schilling, Curt >> | 36 | 2002 | R | 93 | 33 | 33 | 16 | 11 | 4.41 | .310 | 1.32 | 9.6 | 2.3 | 8.8 | 222.1 | 237 | 114 | 109 | 31 | 56 | 217 | 4 | 0 | 0 | 1 | 19 | 7 | 6 | 3.71 |
| SP | Buehrle, M.Buehrle, Mark >> | 22 | 2001 | L | 69 | 33 | 33 | 3 | 17 | 5.91 | .350 | 1.58 | 11.1 | 3.1 | 5.9 | 175.0 | 216 | 122 | 115 | 41 | 60 | 114 | 0 | 0 | 0 | 0 | 15 | 7 | 2 | 5.89 |
| SP | Willis, D.Willis, Dontrelle # >> | 23 | 2005 | L | 49 | 32 | 32 | 10 | 12 | 4.06 | .308 | 1.30 | 8.9 | 2.9 | 6.3 | 201.2 | 198 | 97 | 91 | 27 | 64 | 140 | 0 | 0 | 0 | 0 | 18 | 7 | 2 | 4.41 |
| SP | Beckett, J.Beckett, Josh # >> | 27 | 2007 | R | 48 | 32 | 32 | 9 | 11 | 5.05 | .318 | 1.38 | 9.5 | 2.9 | 7.1 | 214.0 | 226 | 125 | 120 | 32 | 69 | 170 | 3 | 0 | 0 | 0 | 15 | 5 | 0 | 4.39 |
| SP | Jimenez, U.Jimenez, Ubaldo | 25 | 2009 | R | 35 | 31 | 31 | 9 | 14 | 6.21 | .357 | 1.62 | 10.1 | 4.5 | 6.8 | 172.1 | 193 | 124 | 119 | 29 | 86 | 129 | 0 | 0 | 0 | 0 | 9 | 8 | 9 | 5.33 |
| RP | Zumaya, J.Zumaya, Joel >> | 22 | 2006 | R | 34 | 66 | 0 | 2 | 3 | 3.84 | .291 | 1.23 | 6.0 | 5.3 | 7.9 | 65.2 | 43 | 31 | 28 | 8 | 38 | 57 | 0 | 14 | 3 | 0 | 0 | 0 | 6 | 4.60 |
| RP | Farnsworth, K.Farnsworth, Kyle >> | 25 | 2001 | R | 23 | 48 | 0 | 0 | 3 | 5.22 | .364 | 1.66 | 9.9 | 5.0 | 9.2 | 50.0 | 55 | 30 | 29 | 5 | 28 | 51 | 0 | 3 | 1 | 0 | 0 | 3 | 0 | 4.12 |