| SP | Schilling, C.Schilling, Curt >> | 36 | 2002 | R | 93 | 10 | 10 | 5 | 4 | 3.44 | .300 | 1.27 | 8.6 | 2.9 | 8.6 | 65.1 | 62 | 27 | 25 | 3 | 21 | 62 | 2 | 0 | 0 | 1 | 7 | 1 | 1 | 2.71 |
| SP | Buehrle, M.Buehrle, Mark >> | 22 | 2001 | L | 69 | 10 | 10 | 0 | 8 | 9.07 | .404 | 2.04 | 14.7 | 3.9 | 6.8 | 44.2 | 72 | 50 | 45 | 15 | 19 | 33 | 0 | 0 | 0 | 0 | 3 | 0 | 0 | 7.23 |
| SP | Willis, D.Willis, Dontrelle # >> | 23 | 2005 | L | 49 | 10 | 10 | 2 | 3 | 4.42 | .319 | 1.41 | 8.7 | 4.0 | 6.1 | 59.0 | 57 | 31 | 29 | 9 | 26 | 40 | 0 | 0 | 0 | 0 | 6 | 0 | 0 | 4.95 |
| SP | Beckett, J.Beckett, Josh >> | 27 | 2007 | R | 48 | 10 | 10 | 2 | 4 | 5.68 | .358 | 1.66 | 11.1 | 3.9 | 5.9 | 63.1 | 78 | 41 | 40 | 7 | 27 | 41 | 0 | 0 | 0 | 0 | 5 | 1 | 0 | 4.48 |
| SP | Jimenez, U.Jimenez, Ubaldo | 25 | 2009 | R | 35 | 10 | 10 | 2 | 6 | 6.47 | .343 | 1.53 | 9.3 | 4.6 | 6.4 | 55.2 | 57 | 42 | 40 | 10 | 28 | 39 | 0 | 0 | 0 | 0 | 2 | 2 | 1 | 5.58 |
| RP | Zumaya, J.Zumaya, Joel >> | 22 | 2006 | R | 34 | 23 | 0 | 0 | 1 | 4.43 | .272 | 1.12 | 4.9 | 5.3 | 8.6 | 22.1 | 12 | 14 | 11 | 5 | 13 | 21 | 0 | 5 | 1 | 0 | 0 | 0 | 2 | 5.82 |
| RP | Farnsworth, K.Farnsworth, Kyle >> | 25 | 2001 | R | 23 | 15 | 0 | 0 | 0 | 1.59 | .250 | 1.00 | 5.8 | 3.2 | 9.5 | 17.0 | 11 | 4 | 3 | 1 | 6 | 18 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 2.71 |