| SP | Harden, R.Harden, Rich >> | 27 | 2008 | R | 95 | 15 | 15 | 5 | 4 | 4.18 | .312 | 1.33 | 7.7 | 4.3 | 7.3 | 92.2 | 79 | 43 | 43 | 11 | 44 | 75 | 0 | 0 | 0 | 0 | 6 | 3 | 0 | 4.46 |
| SP | Duchscherer, J.Duchscherer, Justin >> | 31 | 2008 | R | 86 | 15 | 15 | 3 | 9 | 5.48 | .360 | 1.63 | 11.0 | 3.8 | 4.6 | 93.2 | 114 | 60 | 57 | 12 | 39 | 48 | 1 | 0 | 0 | 0 | 8 | 5 | 2 | 5.06 |
| SP | Hamels, C.Hamels, Cole >> | 25 | 2008 | L | 73 | 15 | 15 | 5 | 8 | 5.17 | .368 | 1.71 | 11.8 | 3.7 | 6.6 | 85.1 | 111 | 52 | 49 | 11 | 35 | 62 | 0 | 0 | 0 | 0 | 9 | 3 | 0 | 4.56 |
| SP | Maine, J.Maine, John # >> | 25 | 2006 | R | 70 | 15 | 15 | 4 | 5 | 3.93 | .313 | 1.34 | 9.2 | 2.9 | 5.9 | 89.1 | 91 | 45 | 39 | 15 | 29 | 58 | 0 | 0 | 0 | 0 | 8 | 2 | 1 | 4.93 |
| SP | Shields, J.Shields, James >> | 26 | 2007 | R | 54 | 15 | 15 | 5 | 6 | 6.60 | .357 | 1.61 | 11.7 | 2.9 | 6.5 | 91.1 | 118 | 69 | 67 | 19 | 29 | 66 | 0 | 0 | 0 | 0 | 4 | 5 | 7 | 5.38 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 26 | 2006 | R | 94 | 40 | 0 | 2 | 1 | 2.65 | .244 | 0.97 | 6.5 | 2.3 | 9.1 | 68.0 | 49 | 20 | 20 | 6 | 17 | 69 | 0 | 2 | 1 | 0 | 0 | 0 | 0 | 2.87 |
| RP | Foulke, K.Foulke, Keith >> | 31 | 2003 | R | 78 | 38 | 0 | 2 | 3 | 4.25 | .313 | 1.31 | 8.3 | 3.4 | 8.7 | 55.0 | 51 | 26 | 26 | 6 | 21 | 53 | 0 | 4 | 3 | 0 | 0 | 3 | 0 | 3.80 |
| RP | Rodriguez, F.Rodriguez, Felix >> | 29 | 2001 | R | 58 | 37 | 0 | 3 | 2 | 2.17 | .248 | 0.99 | 5.8 | 3.2 | 11.9 | 37.1 | 24 | 11 | 9 | 4 | 13 | 49 | 0 | 4 | 0 | 0 | 0 | 0 | 0 | 2.81 |
| RP | Manzanillo, J.Manzanillo, Josias >> | 34 | 2001 | R | 31 | 20 | 0 | 0 | 1 | 6.86 | .404 | 2.03 | 12.3 | 6.6 | 9.9 | 19.2 | 26 | 16 | 15 | 3 | 14 | 21 | 0 | 0 | 1 | 0 | 0 | 0 | 3 | 5.05 |
| SP | Millwood, K.Millwood, Kevin >> | 28 | 2002 | R | 53 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Dempster, R.Dempster, Ryan >> | 31 | 2008 | R | 39 | 5 | 0 | 1 | 0 | 2.03 | .310 | 1.35 | 6.2 | 6.2 | 6.9 | 13.1 | 9 | 3 | 3 | 0 | 9 | 10 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 3.54 |