| SP | Liriano, F.Liriano, Francisco >> | 23 | 2006 | L | 98 | 24 | 24 | 5 | 4 | 3.22 | .292 | 1.22 | 8.5 | 2.5 | 9.1 | 114.2 | 108 | 42 | 41 | 8 | 32 | 115 | 0 | 0 | 0 | 0 | 3 | 2 | 3 | 2.79 |
| SP | Weaver, J.Weaver, Jered # >> | 24 | 2006 | R | 83 | 24 | 24 | 10 | 11 | 4.74 | .321 | 1.40 | 10.4 | 2.2 | 7.0 | 163.1 | 189 | 89 | 86 | 32 | 40 | 127 | 1 | 0 | 0 | 0 | 13 | 3 | 1 | 4.79 |
| SP | Mussina, M.Mussina, Mike >> | 33 | 2001 | R | 67 | 23 | 23 | 9 | 8 | 4.90 | .318 | 1.32 | 9.5 | 2.4 | 6.6 | 159.2 | 168 | 93 | 87 | 24 | 42 | 116 | 5 | 0 | 0 | 2 | 9 | 13 | 8 | 4.54 |
| SP | Nolasco, R.Nolasco, Ricky # >> | 26 | 2008 | R | 55 | 23 | 23 | 10 | 10 | 5.75 | .326 | 1.43 | 10.9 | 2.0 | 6.1 | 145.2 | 176 | 97 | 93 | 38 | 33 | 99 | 0 | 0 | 0 | 0 | 9 | 2 | 0 | 5.77 |
| SP | Harang, A.Harang, Aaron >> | 29 | 2007 | R | 50 | 23 | 23 | 8 | 9 | 5.05 | .341 | 1.52 | 11.0 | 2.8 | 7.6 | 137.1 | 167 | 83 | 77 | 23 | 42 | 116 | 0 | 0 | 0 | 0 | 12 | 4 | 3 | 4.50 |
| RP | Percival, T.Percival, Troy >> | 38 | 2007 | R | 84 | 57 | 0 | 6 | 2 | 3.39 | .282 | 1.15 | 7.5 | 3.0 | 6.8 | 79.2 | 66 | 30 | 30 | 11 | 26 | 60 | 0 | 5 | 3 | 0 | 0 | 2 | 3 | 4.35 |
| RP | Sasaki, K.Sasaki, Kazuhiro >> | 33 | 2001 | R | 63 | 54 | 0 | 3 | 1 | 3.66 | .289 | 1.22 | 7.5 | 3.5 | 7.2 | 64.0 | 53 | 28 | 26 | 8 | 25 | 51 | 0 | 7 | 0 | 0 | 0 | 0 | 5 | 4.20 |
| RP | Cordero, C.Cordero, Chad >> | 23 | 2005 | R | 49 | 37 | 0 | 2 | 3 | 4.37 | .327 | 1.39 | 9.4 | 3.3 | 5.4 | 47.1 | 49 | 27 | 23 | 8 | 17 | 28 | 0 | 2 | 0 | 0 | 0 | 3 | 0 | 5.30 |
| SP | Verlander, J.Verlander, Justin >> | 26 | 2009 | R | 43 | 2 | 0 | 1 | 0 | 1.23 | .241 | 0.95 | 7.7 | 1.3 | 7.7 | 7.1 | 6 | 1 | 1 | 0 | 1 | 6 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1.71 |
| SP | Kazmir, S.Kazmir, Scott >> | 24 | 2008 | L | 40 | 20 | 0 | 1 | 2 | 6.99 | .364 | 1.66 | 10.2 | 4.9 | 7.5 | 37.1 | 42 | 29 | 29 | 11 | 20 | 31 | 0 | 3 | 1 | 0 | 0 | 2 | 0 | 6.97 |