| SP | Johnson, R.Johnson, Randy † >> | 38 | 2001 | L | 97 | 36 | 36 | 14 | 13 | 3.36 | .309 | 1.31 | 8.2 | 3.6 | 10.2 | 254.1 | 231 | 110 | 95 | 32 | 101 | 288 | 3 | 0 | 0 | 2 | 21 | 9 | 4 | 3.67 |
| SP | Duchscherer, J.Duchscherer, Justin † >> | 31 | 2008 | R | 85 | 34 | 34 | 14 | 10 | 3.96 | .308 | 1.29 | 8.8 | 2.8 | 6.7 | 218.1 | 212 | 106 | 96 | 26 | 69 | 163 | 1 | 0 | 0 | 0 | 19 | 10 | 1 | 4.14 |
| SP | Zambrano, C.Zambrano, Carlos # >> | 24 | 2005 | R | 70 | 32 | 32 | 13 | 10 | 4.85 | .325 | 1.39 | 8.6 | 3.9 | 7.1 | 196.2 | 188 | 109 | 106 | 24 | 86 | 155 | 3 | 0 | 0 | 2 | 16 | 10 | 2 | 4.48 |
| CL | Soriano, R.Soriano, Rafael >> | 24 | 2003 | R | 97 | 68 | 0 | 5 | 9 | 3.31 | .276 | 1.13 | 8.0 | 2.3 | 10.8 | 70.2 | 62 | 26 | 26 | 7 | 18 | 84 | 0 | 38 | 5 | 0 | 0 | 1 | 0 | 2.71 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 79 | 93 | 0 | 6 | 4 | 4.18 | .313 | 1.33 | 5.9 | 6.1 | 9.4 | 75.1 | 49 | 36 | 35 | 7 | 51 | 78 | 0 | 0 | 2 | 0 | 0 | 3 | 3 | 4.29 |
| RP | Cormier, R.Cormier, Rheal >> | 36 | 2003 | L | 62 | 95 | 0 | 2 | 0 | 2.57 | .279 | 1.16 | 7.1 | 3.4 | 5.9 | 56.0 | 44 | 17 | 16 | 5 | 21 | 37 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 3.96 |
| RP | Hoffman, T.Hoffman, Trevor >> | 42 | 2009 | R | 70 | 38 | 0 | 5 | 2 | 3.34 | .331 | 1.46 | 9.5 | 3.6 | 8.0 | 35.0 | 37 | 13 | 13 | 2 | 14 | 31 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 3.26 |
| RP | Okajima, H.Okajima, Hideki >> | 32 | 2007 | L | 52 | 65 | 0 | 4 | 1 | 2.45 | .270 | 1.09 | 6.9 | 2.9 | 7.2 | 55.0 | 42 | 16 | 15 | 6 | 18 | 44 | 0 | 1 | 2 | 0 | 0 | 1 | 0 | 3.85 |
| SP | Clement, M.Clement, Matt >> | 28 | 2002 | R | 53 | 29 | 1 | 2 | 1 | 4.50 | .339 | 1.50 | 8.7 | 4.8 | 9.1 | 96.0 | 93 | 49 | 48 | 11 | 51 | 97 | 0 | 1 | 0 | 0 | 0 | 4 | 7 | 4.19 |