| SP | Scherzer, M.Scherzer, Max >> | 33 | 2017 | R | 97 | 23 | 23 | 10 | 11 | 4.03 | .297 | 1.22 | 7.7 | 3.3 | 10.5 | 140.2 | 119 | 64 | 63 | 16 | 52 | 163 | 0 | 0 | 0 | 0 | 14 | 7 | 4 | 3.42 |
| SP | Richard, J.Richard, J.R. >> | 30 | 1980 | R | 93 | 22 | 22 | 8 | 11 | 3.42 | .279 | 1.15 | 6.6 | 3.8 | 8.8 | 157.2 | 115 | 61 | 60 | 13 | 66 | 153 | 4 | 0 | 0 | 1 | 14 | 2 | 4 | 3.43 |
| SP | Fernandez, J.Fernandez, Jose † >> | 21 | 2013 | R | 83 | 21 | 21 | 13 | 3 | 2.65 | .281 | 1.14 | 6.9 | 3.4 | 8.2 | 153.0 | 117 | 47 | 45 | 17 | 58 | 140 | 3 | 0 | 0 | 1 | 17 | 4 | 1 | 3.83 |
| SP | Harden, R.Harden, Rich >> | 27 | 2008 | R | 68 | 20 | 20 | 8 | 8 | 4.21 | .321 | 1.42 | 8.2 | 4.6 | 7.5 | 128.1 | 117 | 62 | 60 | 14 | 65 | 107 | 2 | 0 | 0 | 1 | 11 | 0 | 2 | 4.27 |
| RP | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 86 | 42 | 0 | 3 | 0 | 2.59 | .205 | 0.77 | 5.1 | 2.0 | 9.0 | 55.2 | 31 | 16 | 16 | 6 | 12 | 55 | 0 | 5 | 4 | 0 | 0 | 0 | 0 | 3.07 |
| RP | Williams, D.Williams, Devin >> | 28 | 2023 | R | 70 | 11 | 0 | 0 | 0 | 1.32 | .241 | 0.95 | 4.2 | 4.8 | 9.7 | 13.2 | 6 | 2 | 2 | 0 | 7 | 14 | 0 | 3 | 0 | 0 | 0 | 0 | 1 | 2.46 |
| RP | Saucier, K.Saucier, Kevin >> | 25 | 1981 | L | 55 | 8 | 0 | 2 | 0 | 3.68 | .333 | 1.50 | 7.7 | 6.4 | 9.0 | 7.1 | 6 | 3 | 3 | 1 | 5 | 7 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 5.00 |
| RP | Eichhorn, M.Eichhorn, Mark >> | 26 | 1986 | R | 47 | 11 | 0 | 0 | 0 | 2.55 | .264 | 1.08 | 6.4 | 3.7 | 5.3 | 17.2 | 12 | 5 | 5 | 1 | 7 | 10 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.82 |
| SP | Darvish, Y.Darvish, Yu >> | 26 | 2013 | R | 57 | 12 | 0 | 1 | 0 | 1.99 | .280 | 1.15 | 5.6 | 4.9 | 8.9 | 63.1 | 39 | 14 | 14 | 3 | 34 | 62 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 3.32 |