| SP | McLain, D.McLain, Denny >> | 24 | 1968 | R | 79 | 31 | 31 | 10 | 16 | 7.51 | .381 | 1.83 | 12.5 | 4.0 | 5.0 | 191.2 | 265 | 167 | 160 | 39 | 85 | 107 | 7 | 0 | 0 | 0 | 5 | 4 | 4 | 5.93 |
| SP | Waddell, R.Waddell, Rube >> | 29 | 1905 | L | 67 | 30 | 30 | 10 | 7 | 5.46 | .329 | 1.44 | 9.0 | 4.0 | 5.3 | 201.0 | 201 | 131 | 122 | 30 | 89 | 118 | 0 | 0 | 0 | 0 | 12 | 5 | 3 | 5.17 |
| RP | Feliz, N.Feliz, Neftali >> | 21 | 2009 | R | 97 | 84 | 0 | 4 | 3 | 3.09 | .270 | 1.07 | 5.7 | 3.9 | 8.1 | 102.0 | 65 | 35 | 35 | 3 | 44 | 92 | 0 | 9 | 2 | 0 | 0 | 4 | 0 | 2.99 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 84 | 0 | 4 | 6 | 3.87 | .315 | 1.34 | 7.9 | 4.2 | 9.5 | 102.1 | 89 | 44 | 44 | 8 | 48 | 108 | 0 | 6 | 6 | 0 | 0 | 4 | 0 | 3.43 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 85 | 51 | 0 | 7 | 1 | 4.78 | .294 | 1.23 | 9.1 | 2.0 | 6.9 | 64.0 | 65 | 37 | 34 | 8 | 14 | 49 | 0 | 3 | 1 | 0 | 0 | 1 | 5 | 3.80 |
| RP | Britton, Z.Britton, Zach >> | 28 | 2016 | L | 78 | 47 | 0 | 4 | 3 | 4.07 | .306 | 1.29 | 7.9 | 3.8 | 8.4 | 59.2 | 52 | 27 | 27 | 10 | 25 | 55 | 0 | 6 | 3 | 0 | 0 | 2 | 10 | 4.71 |