| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 32 | 32 | 11 | 14 | 4.64 | .315 | 1.37 | 9.5 | 2.9 | 10.2 | 197.2 | 208 | 109 | 102 | 23 | 63 | 224 | 1 | 0 | 0 | 1 | 18 | 2 | 0 | 3.23 |
| SP | Scherzer, M.Scherzer, Max >> | 33 | 2017 | R | 95 | 31 | 31 | 11 | 14 | 3.83 | .314 | 1.35 | 8.4 | 3.8 | 8.1 | 206.2 | 192 | 99 | 88 | 19 | 88 | 185 | 1 | 0 | 0 | 1 | 16 | 4 | 6 | 3.74 |
| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 92 | 30 | 30 | 10 | 13 | 5.12 | .338 | 1.51 | 10.5 | 3.2 | 7.7 | 202.1 | 235 | 125 | 115 | 22 | 71 | 172 | 4 | 0 | 0 | 0 | 12 | 4 | 5 | 3.83 |
| RP | Jansen, K.Jansen, Kenley >> | 28 | 2016 | R | 97 | 85 | 0 | 4 | 6 | 4.32 | .330 | 1.45 | 9.4 | 3.6 | 8.0 | 102.0 | 107 | 56 | 49 | 14 | 41 | 91 | 0 | 6 | 0 | 0 | 0 | 3 | 0 | 4.29 |
| RP | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 88 | 77 | 0 | 5 | 1 | 1.50 | .236 | 0.91 | 6.5 | 1.8 | 6.1 | 101.2 | 73 | 18 | 17 | 4 | 20 | 69 | 0 | 10 | 4 | 0 | 0 | 1 | 0 | 2.77 |
| RP | Clippard, T.Clippard, Tyler >> | 26 | 2011 | R | 79 | 33 | 0 | 1 | 2 | 2.65 | .292 | 1.24 | 7.1 | 4.0 | 8.2 | 34.0 | 27 | 12 | 10 | 3 | 15 | 31 | 0 | 3 | 2 | 0 | 0 | 0 | 0 | 3.65 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 75 | 22 | 0 | 0 | 3 | 2.27 | .296 | 1.26 | 7.3 | 4.4 | 8.4 | 31.2 | 25 | 11 | 8 | 2 | 15 | 29 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 3.42 |