| SP | Leonard, D.Leonard, Dutch † >> | 22 | 1914 | L | 91 | 31 | 31 | 17 | 10 | 2.89 | .287 | 1.18 | 7.6 | 3.0 | 5.6 | 215.0 | 182 | 78 | 69 | 11 | 72 | 134 | 0 | 0 | 0 | 0 | 21 | 5 | 2 | 3.49 |
| SP | Kluber, C.Kluber, Corey >> | 31 | 2017 | R | 90 | 31 | 31 | 12 | 11 | 5.23 | .322 | 1.41 | 9.5 | 3.3 | 8.3 | 211.2 | 222 | 132 | 123 | 37 | 77 | 194 | 3 | 0 | 0 | 0 | 12 | 3 | 3 | 4.58 |
| SP | Clemens, R.Clemens, Roger † >> | 24 | 1986 | R | 69 | 31 | 30 | 12 | 9 | 4.05 | .312 | 1.34 | 8.6 | 3.4 | 5.3 | 229.0 | 220 | 111 | 103 | 30 | 87 | 135 | 14 | 0 | 0 | 1 | 18 | 5 | 6 | 4.73 |
| SP | Caldwell, R.Caldwell, Ray >> | 26 | 1914 | R | 64 | 29 | 29 | 11 | 11 | 5.45 | .343 | 1.55 | 10.3 | 3.7 | 4.7 | 178.1 | 204 | 110 | 108 | 21 | 73 | 93 | 0 | 0 | 0 | 0 | 14 | 2 | 3 | 4.75 |
| RP | Kimbrel, C.Kimbrel, Craig † >> | 24 | 2012 | R | 100 | 90 | 0 | 9 | 7 | 2.88 | .273 | 1.09 | 5.9 | 4.0 | 9.2 | 109.1 | 71 | 36 | 35 | 7 | 48 | 112 | 0 | 17 | 4 | 0 | 0 | 4 | 6 | 3.21 |
| RP | Wagner, B.Wagner, Billy >> | 28 | 1999 | L | 95 | 61 | 0 | 4 | 0 | 2.14 | .252 | 1.00 | 5.4 | 3.6 | 9.9 | 80.0 | 48 | 21 | 19 | 1 | 32 | 88 | 0 | 10 | 2 | 0 | 0 | 1 | 1 | 2.20 |
| RP | Benitez, A.Benitez, Armando >> | 32 | 2004 | R | 82 | 29 | 0 | 0 | 3 | 2.59 | .271 | 1.12 | 6.4 | 3.8 | 7.0 | 31.1 | 22 | 9 | 9 | 2 | 13 | 24 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 3.55 |
| RP | Treinen, B.Treinen, Blake >> | 30 | 2018 | R | 80 | 27 | 0 | 1 | 2 | 3.93 | .327 | 1.43 | 9.5 | 3.4 | 9.8 | 34.1 | 36 | 15 | 15 | 3 | 13 | 37 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 3.21 |