| SP | Kershaw, C.Kershaw, Clayton † >> | 28 | 2016 | L | 99 | 36 | 36 | 22 | 8 | 3.12 | .265 | 1.06 | 7.5 | 2.1 | 8.1 | 274.1 | 228 | 99 | 95 | 31 | 64 | 247 | 8 | 0 | 0 | 2 | 24 | 4 | 5 | 3.41 |
| SP | Hunter, C.Hunter, Catfish >> | 26 | 1972 | R | 81 | 34 | 34 | 16 | 13 | 5.28 | .328 | 1.44 | 9.8 | 3.2 | 5.5 | 231.2 | 251 | 150 | 136 | 45 | 82 | 140 | 3 | 0 | 0 | 0 | 12 | 6 | 6 | 5.46 |
| SP | Bender, C.Bender, Chief >> | 26 | 1910 | R | 72 | 33 | 33 | 8 | 19 | 5.42 | .324 | 1.43 | 9.9 | 2.9 | 5.1 | 229.0 | 252 | 144 | 138 | 39 | 75 | 130 | 5 | 0 | 0 | 1 | 11 | 2 | 6 | 5.09 |
| SP | Clemens, R.Clemens, Roger # >> | 24 | 1986 | R | 69 | 32 | 31 | 16 | 8 | 4.24 | .295 | 1.23 | 8.2 | 2.9 | 6.5 | 227.1 | 207 | 113 | 107 | 39 | 73 | 163 | 3 | 0 | 0 | 0 | 17 | 5 | 3 | 4.83 |
| RP | Clippard, T.Clippard, Tyler >> | 26 | 2011 | R | 80 | 61 | 0 | 2 | 4 | 3.60 | .301 | 1.29 | 7.1 | 4.6 | 9.0 | 65.0 | 51 | 27 | 26 | 6 | 33 | 65 | 0 | 2 | 2 | 0 | 0 | 0 | 1 | 3.72 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 75 | 39 | 0 | 2 | 1 | 2.57 | .319 | 1.37 | 6.1 | 6.2 | 8.4 | 49.0 | 33 | 15 | 14 | 5 | 34 | 46 | 0 | 0 | 1 | 0 | 0 | 2 | 3 | 4.65 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 75 | 38 | 0 | 0 | 2 | 7.04 | .382 | 1.85 | 10.2 | 6.6 | 10.4 | 38.1 | 43 | 31 | 30 | 10 | 28 | 44 | 0 | 3 | 0 | 0 | 0 | 0 | 3 | 6.32 |
| CL | Doolittle, S.Doolittle, Sean † >> | 31 | 2018 | L | 98 | 74 | 0 | 3 | 11 | 3.39 | .280 | 1.15 | 7.5 | 3.0 | 7.7 | 79.2 | 66 | 34 | 30 | 10 | 26 | 68 | 0 | 37 | 7 | 0 | 0 | 1 | 2 | 3.95 |