| SP | Leonard, D.Leonard, Dutch † >> | 22 | 1914 | L | 91 | 21 | 21 | 13 | 4 | 2.15 | .244 | 0.96 | 5.8 | 2.8 | 5.9 | 146.1 | 94 | 39 | 35 | 6 | 46 | 95 | 0 | 0 | 0 | 0 | 16 | 2 | 3 | 3.22 |
| SP | Brown, M.Brown, Mordecai † >> | 32 | 1908 | R | 85 | 21 | 21 | 15 | 5 | 3.07 | .273 | 1.09 | 7.4 | 2.4 | 3.4 | 161.1 | 133 | 58 | 55 | 11 | 43 | 60 | 6 | 0 | 0 | 2 | 14 | 6 | 3 | 4.06 |
| SP | Cicotte, E.Cicotte, Eddie >> | 33 | 1917 | R | 73 | 22 | 22 | 9 | 10 | 4.15 | .284 | 1.16 | 7.5 | 3.0 | 4.1 | 165.0 | 137 | 77 | 76 | 23 | 55 | 76 | 7 | 0 | 0 | 3 | 9 | 4 | 0 | 4.96 |
| SP | Harden, R.Harden, Rich >> | 27 | 2008 | R | 60 | 20 | 20 | 7 | 9 | 3.41 | .319 | 1.38 | 6.9 | 5.6 | 8.2 | 118.2 | 91 | 47 | 45 | 11 | 73 | 108 | 0 | 0 | 0 | 0 | 10 | 3 | 3 | 4.31 |
| RP | Feliz, N.Feliz, Neftali >> | 21 | 2009 | R | 97 | 54 | 0 | 2 | 0 | 2.02 | .258 | 1.05 | 5.4 | 4.1 | 8.9 | 80.1 | 48 | 19 | 18 | 3 | 36 | 79 | 0 | 13 | 1 | 0 | 0 | 0 | 0 | 2.86 |
| RP | Boxberger, B.Boxberger, Brad >> | 26 | 2014 | R | 83 | 15 | 0 | 1 | 1 | 1.80 | .224 | 0.80 | 4.2 | 3.0 | 10.2 | 15.0 | 7 | 3 | 3 | 0 | 5 | 17 | 0 | 4 | 0 | 0 | 0 | 1 | 0 | 1.93 |
| RP | Urbina, U.Urbina, Ugueth >> | 24 | 1998 | R | 58 | 4 | 0 | 1 | 0 | 0.00 | .333 | 1.50 | 18.0 | 0.0 | 0.0 | 2.2 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 3.00 |
| RP | Eichhorn, M.Eichhorn, Mark >> | 26 | 1986 | R | 48 | 4 | 0 | 0 | 0 | 0.00 | .294 | 1.25 | 6.8 | 4.5 | 6.8 | 4.0 | 3 | 1 | 0 | 0 | 2 | 3 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 3.00 |
| RP | Messersmith, A.Messersmith, Andy >> | 23 | 1968 | R | 57 | 6 | 0 | 0 | 0 | 6.10 | .392 | 1.94 | 11.7 | 6.3 | 4.5 | 10.1 | 13 | 7 | 7 | 3 | 7 | 5 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 8.00 |
| SP | Drysdale, D.Drysdale, Don >> | 28 | 1964 | R | 58 | 7 | 0 | 2 | 0 | 2.60 | .273 | 1.13 | 8.7 | 1.6 | 5.0 | 34.2 | 33 | 14 | 10 | 3 | 6 | 19 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.56 |