| SP | Koufax, S.Koufax, Sandy >> | 30 | 1965 | L | 98 | 23 | 23 | 10 | 9 | 4.13 | .286 | 1.19 | 8.3 | 2.4 | 8.9 | 157.0 | 145 | 81 | 72 | 21 | 42 | 155 | 6 | 0 | 0 | 3 | 8 | 2 | 5 | 3.61 |
| SP | Maddux, G.Maddux, Greg † >> | 29 | 1995 | R | 89 | 22 | 22 | 11 | 8 | 3.53 | .286 | 1.18 | 8.7 | 1.9 | 4.9 | 148.0 | 143 | 61 | 58 | 23 | 31 | 81 | 8 | 0 | 0 | 1 | 14 | 4 | 1 | 4.64 |
| RP | Wagner, B.Wagner, Billy >> | 28 | 1999 | L | 95 | 49 | 0 | 4 | 3 | 3.86 | .323 | 1.40 | 7.7 | 5.1 | 10.2 | 60.2 | 51 | 28 | 26 | 6 | 34 | 68 | 0 | 5 | 3 | 0 | 0 | 2 | 3 | 3.83 |
| RP | Saito, T.Saito, Takashi >> | 37 | 2007 | R | 91 | 38 | 0 | 3 | 1 | 4.23 | .311 | 1.36 | 9.2 | 3.1 | 8.3 | 55.1 | 56 | 27 | 26 | 9 | 19 | 51 | 0 | 4 | 1 | 0 | 0 | 0 | 0 | 4.31 |
| RP | Soriano, R.Soriano, Rafael >> | 24 | 2003 | R | 84 | 36 | 0 | 4 | 3 | 3.51 | .281 | 1.11 | 7.3 | 2.8 | 7.5 | 48.2 | 39 | 20 | 19 | 7 | 15 | 40 | 0 | 2 | 2 | 0 | 0 | 3 | 0 | 4.35 |
| RP | Britton, Z.Britton, Zach >> | 28 | 2016 | L | 78 | 12 | 0 | 2 | 0 | 8.71 | .380 | 1.84 | 9.9 | 7.2 | 8.1 | 10.1 | 11 | 11 | 10 | 3 | 8 | 9 | 0 | 0 | 1 | 0 | 0 | 0 | 2 | 7.50 |
| RP | Wilhelm, H.Wilhelm, Hoyt >> | 43 | 1965 | R | 68 | 16 | 0 | 0 | 3 | 4.80 | .274 | 1.13 | 8.1 | 2.1 | 4.5 | 30.0 | 27 | 16 | 16 | 6 | 7 | 15 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 5.30 |
| RP | Dotel, O.Dotel, Octavio >> | 29 | 2002 | R | 69 | 15 | 0 | 0 | 0 | 3.31 | .290 | 1.22 | 7.3 | 3.9 | 7.3 | 16.1 | 13 | 6 | 6 | 2 | 7 | 13 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.31 |
| SP | Hendrix, C.Hendrix, Claude >> | 25 | 1914 | R | 69 | 11 | 2 | 1 | 4 | 6.04 | .349 | 1.57 | 10.8 | 3.5 | 4.5 | 56.2 | 67 | 43 | 38 | 11 | 22 | 28 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 5.84 |