| SP | Scherzer, M.Scherzer, Max # >> | 33 | 2017 | R | 95 | 35 | 35 | 10 | 15 | 4.75 | .329 | 1.45 | 8.5 | 4.6 | 9.4 | 189.1 | 179 | 107 | 100 | 16 | 96 | 197 | 0 | 0 | 0 | 0 | 19 | 3 | 4 | 3.59 |
| SP | Maddux, G.Maddux, Greg # >> | 29 | 1995 | R | 89 | 35 | 35 | 19 | 9 | 2.92 | .257 | 1.02 | 7.6 | 1.5 | 5.6 | 256.0 | 216 | 90 | 83 | 14 | 44 | 158 | 11 | 0 | 0 | 2 | 25 | 5 | 2 | 3.05 |
| SP | Brown, M.Brown, Mordecai † >> | 32 | 1908 | R | 85 | 35 | 35 | 14 | 12 | 3.69 | .298 | 1.26 | 8.7 | 2.7 | 3.8 | 234.1 | 225 | 106 | 96 | 26 | 70 | 100 | 4 | 0 | 0 | 0 | 21 | 3 | 3 | 4.53 |
| SP | Pfiester, J.Pfiester, Jack >> | 28 | 1906 | L | 74 | 33 | 33 | 11 | 11 | 5.18 | .331 | 1.46 | 9.8 | 3.4 | 5.6 | 199.2 | 217 | 126 | 115 | 27 | 75 | 124 | 5 | 0 | 0 | 1 | 12 | 5 | 3 | 4.72 |
| RP | Williams, D.Williams, Devin >> | 28 | 2023 | R | 73 | 84 | 0 | 4 | 1 | 3.79 | .333 | 1.46 | 7.7 | 5.5 | 10.2 | 95.0 | 81 | 42 | 40 | 11 | 58 | 108 | 0 | 3 | 3 | 0 | 0 | 3 | 2 | 4.16 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 71 | 75 | 0 | 3 | 3 | 3.32 | .322 | 1.40 | 6.3 | 6.3 | 9.0 | 81.1 | 57 | 33 | 30 | 8 | 57 | 81 | 0 | 7 | 3 | 0 | 0 | 2 | 3 | 4.47 |
| RP | Boxberger, B.Boxberger, Brad >> | 26 | 2014 | R | 83 | 61 | 0 | 4 | 3 | 4.48 | .317 | 1.39 | 7.4 | 5.2 | 9.3 | 68.1 | 56 | 35 | 34 | 7 | 39 | 70 | 0 | 1 | 0 | 0 | 0 | 0 | 4 | 4.00 |
| RP | Benitez, A.Benitez, Armando >> | 32 | 2004 | R | 82 | 49 | 0 | 1 | 2 | 3.96 | .263 | 1.04 | 6.1 | 3.3 | 5.9 | 63.2 | 43 | 32 | 28 | 6 | 23 | 41 | 0 | 1 | 3 | 0 | 0 | 2 | 0 | 4.13 |
| RP | Campbell, B.Campbell, Bill >> | 28 | 1976 | R | 2 | 34 | 0 | 4 | 1 | 5.96 | .349 | 1.59 | 10.0 | 4.4 | 5.4 | 45.1 | 50 | 32 | 30 | 7 | 22 | 27 | 0 | 0 | 1 | 0 | 0 | 1 | 2 | 5.36 |
| CL | Uehara, K.Uehara, Koji † >> | 38 | 2013 | R | 100 | 65 | 0 | 7 | 7 | 2.65 | .255 | 1.03 | 6.8 | 2.5 | 9.8 | 68.0 | 51 | 22 | 20 | 6 | 19 | 74 | 0 | 36 | 4 | 0 | 0 | 0 | 1 | 2.81 |