| SP | Mathewson, C.Mathewson, Christy † $$ >> | 28 | 1908 | R | 83 | 36 | 36 | 19 | 6 | 3.08 | .256 | 1.01 | 7.3 | 1.8 | 4.5 | 274.2 | 222 | 95 | 94 | 26 | 56 | 137 | 4 | 0 | 0 | 0 | 25 | 6 | 2 | 3.91 |
| SP | Fernandez, S.Fernandez, Sid >> | 23 | 1985 | L | 49 | 34 | 34 | 16 | 8 | 3.12 | .294 | 1.21 | 6.5 | 4.4 | 7.8 | 239.1 | 173 | 86 | 83 | 22 | 116 | 207 | 3 | 0 | 0 | 0 | 25 | 10 | 1 | 4.05 |
| SP | Fernandez, J.Fernandez, Jose >> | 21 | 2013 | R | 76 | 34 | 34 | 13 | 8 | 3.76 | .318 | 1.38 | 8.5 | 3.9 | 6.7 | 215.1 | 204 | 93 | 90 | 28 | 93 | 160 | 1 | 0 | 0 | 1 | 20 | 4 | 2 | 4.56 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 85 | 68 | 0 | 6 | 6 | 2.15 | .217 | 0.83 | 6.2 | 1.3 | 7.9 | 71.0 | 49 | 19 | 17 | 8 | 10 | 62 | 0 | 2 | 3 | 0 | 0 | 0 | 0 | 3.14 |
| RP | Pagan, E.Pagan, Emilio >> | 28 | 2019 | R | 76 | 35 | 0 | 6 | 2 | 1.33 | .192 | 0.69 | 3.6 | 2.7 | 7.4 | 40.2 | 16 | 7 | 6 | 3 | 12 | 33 | 0 | 0 | 2 | 0 | 0 | 1 | 2 | 3.30 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 63 | 31 | 0 | 2 | 4 | 1.80 | .266 | 1.09 | 5.7 | 4.1 | 6.2 | 35.0 | 22 | 7 | 7 | 2 | 16 | 24 | 0 | 0 | 1 | 0 | 0 | 0 | 2 | 3.74 |
| SP | Kluber, C.Kluber, Corey >> | 31 | 2017 | R | 90 | 32 | 32 | 10 | 16 | 4.51 | .286 | 1.18 | 8.4 | 2.2 | 8.0 | 215.2 | 201 | 117 | 108 | 31 | 53 | 190 | 5 | 0 | 0 | 2 | 16 | 5 | 4 | 3.92 |
| CL | Chapman, A.Chapman, Aroldis † $$ >> | 37 | 2025 | L | 96 | 68 | 0 | 3 | 5 | 3.20 | .260 | 1.02 | 5.9 | 3.4 | 7.5 | 64.2 | 42 | 28 | 23 | 6 | 24 | 53 | 0 | 44 | 11 | 0 | 0 | 2 | 9 | 3.78 |
| SP | Reulbach, E.Reulbach, Ed >> | 24 | 1906 | R | 60 | 7 | 1 | 3 | 0 | 1.23 | .241 | 0.91 | 4.5 | 3.7 | 1.6 | 22.0 | 11 | 3 | 3 | 1 | 9 | 4 | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 4.59 |