| SP | Skubal, T.Skubal, Tarik >> | 28 | 2025 | L | 100 | 28 | 28 | 9 | 10 | 3.02 | .275 | 1.10 | 8.0 | 1.9 | 9.9 | 190.2 | 169 | 66 | 64 | 17 | 41 | 210 | 3 | 0 | 0 | 0 | 22 | 7 | 3 | 2.71 |
| SP | Gilbert, L.Gilbert, Logan >> | 28 | 2025 | R | 92 | 29 | 29 | 8 | 11 | 6.20 | .356 | 1.63 | 10.8 | 3.8 | 10.3 | 132.0 | 159 | 91 | 91 | 20 | 56 | 151 | 0 | 0 | 0 | 0 | 5 | 4 | 3 | 4.05 |
| SP | Schwellenbach, S.Schwellenbach, Spencer >> | 25 | 2025 | R | 87 | 27 | 27 | 9 | 9 | 4.83 | .326 | 1.39 | 10.1 | 2.4 | 8.3 | 164.0 | 184 | 89 | 88 | 21 | 44 | 152 | 0 | 0 | 0 | 0 | 14 | 10 | 3 | 3.80 |
| SP | Abbott, A.Abbott, Andrew >> | 26 | 2025 | L | 70 | 28 | 27 | 6 | 9 | 5.27 | .337 | 1.50 | 9.4 | 4.1 | 8.0 | 141.2 | 148 | 90 | 83 | 15 | 64 | 126 | 0 | 0 | 0 | 0 | 10 | 4 | 1 | 4.04 |
| SP | Luzardo, J.Luzardo, Jesus >> | 27 | 2025 | L | 68 | 29 | 26 | 9 | 10 | 4.86 | .336 | 1.49 | 10.0 | 3.4 | 11.0 | 137.0 | 152 | 76 | 74 | 18 | 52 | 167 | 0 | 1 | 0 | 0 | 11 | 4 | 4 | 3.50 |
| RP | Cleavinger, G.Cleavinger, Garrett >> | 31 | 2025 | L | 93 | 93 | 0 | 5 | 2 | 3.47 | .314 | 1.29 | 7.5 | 4.2 | 9.9 | 124.2 | 103 | 50 | 48 | 11 | 58 | 136 | 0 | 3 | 3 | 0 | 0 | 10 | 1 | 3.60 |
| RP | Thielbar, C.Thielbar, Caleb >> | 38 | 2025 | L | 92 | 94 | 0 | 4 | 5 | 3.86 | .297 | 1.21 | 8.0 | 2.9 | 8.5 | 116.2 | 103 | 52 | 50 | 12 | 38 | 110 | 0 | 8 | 2 | 0 | 0 | 7 | 0 | 3.61 |
| RP | Morejon, A.Morejon, Adrian † >> | 26 | 2025 | L | 88 | 84 | 0 | 6 | 3 | 2.39 | .280 | 1.14 | 7.0 | 3.2 | 7.0 | 109.0 | 85 | 29 | 29 | 10 | 39 | 85 | 0 | 12 | 6 | 0 | 0 | 3 | 2 | 3.79 |
| RP | Bautista, F.Bautista, Félix >> | 30 | 2025 | R | 84 | 67 | 0 | 6 | 5 | 3.87 | .297 | 1.18 | 5.0 | 5.7 | 12.3 | 74.1 | 41 | 32 | 32 | 9 | 47 | 101 | 0 | 5 | 3 | 0 | 0 | 6 | 3 | 4.00 |
| RP | Bender, A.Bender, Anthony >> | 30 | 2025 | R | 77 | 61 | 0 | 5 | 6 | 3.39 | .304 | 1.27 | 6.7 | 4.8 | 6.9 | 77.0 | 57 | 32 | 29 | 10 | 41 | 59 | 0 | 3 | 2 | 0 | 0 | 3 | 1 | 4.87 |