| SP | Wainwright, A.Wainwright, Adam >> | 29 | 2010 | R | 98 | 21 | 21 | 6 | 12 | 4.83 | .329 | 1.41 | 9.7 | 3.1 | 7.8 | 128.2 | 138 | 72 | 69 | 15 | 44 | 111 | 0 | 0 | 0 | 0 | 7 | 7 | 5 | 3.98 |
| SP | Liriano, F.Liriano, Francisco # >> | 27 | 2010 | L | 56 | 21 | 21 | 8 | 10 | 4.11 | .325 | 1.41 | 9.6 | 3.1 | 9.0 | 129.1 | 138 | 62 | 59 | 13 | 44 | 129 | 0 | 0 | 0 | 0 | 11 | 5 | 5 | 3.45 |
| SP | Rodriguez, W.Rodriguez, Wandy >> | 31 | 2010 | L | 45 | 20 | 20 | 4 | 11 | 6.60 | .355 | 1.61 | 9.7 | 4.8 | 6.9 | 105.0 | 113 | 82 | 77 | 15 | 56 | 81 | 0 | 0 | 0 | 0 | 8 | 4 | 3 | 5.03 |
| SP | Hunter, T.Hunter, Tommy >> | 24 | 2010 | R | 44 | 20 | 20 | 7 | 5 | 3.55 | .303 | 1.29 | 8.8 | 2.8 | 6.2 | 114.0 | 112 | 47 | 45 | 10 | 35 | 79 | 0 | 0 | 0 | 0 | 9 | 2 | 1 | 3.73 |
| RP | Gregerson, L.Gregerson, Luke >> | 26 | 2010 | R | 97 | 55 | 0 | 2 | 3 | 4.00 | .344 | 1.54 | 10.2 | 3.8 | 9.2 | 78.2 | 88 | 40 | 35 | 10 | 33 | 80 | 0 | 3 | 2 | 0 | 0 | 3 | 0 | 4.00 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 30 | 2010 | R | 38 | 52 | 0 | 3 | 2 | 3.19 | .310 | 1.32 | 9.3 | 2.7 | 9.8 | 67.2 | 69 | 24 | 24 | 6 | 20 | 73 | 0 | 4 | 1 | 0 | 0 | 2 | 4 | 2.97 |
| RP | Villanueva, C.Villanueva, Carlos >> | 27 | 2010 | R | 26 | 44 | 0 | 3 | 0 | 4.78 | .342 | 1.52 | 8.0 | 5.9 | 9.9 | 52.2 | 46 | 28 | 28 | 7 | 34 | 57 | 0 | 1 | 4 | 0 | 0 | 2 | 3 | 4.63 |
| SP | Slowey, K.Slowey, Kevin >> | 26 | 2010 | R | 21 | 4 | 1 | 2 | 0 | 2.57 | .344 | 1.57 | 10.3 | 3.9 | 3.9 | 14.0 | 16 | 4 | 4 | 2 | 6 | 6 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 5.29 |
| SP | Morrow, B.Morrow, Brandon >> | 26 | 2010 | R | 32 | 32 | 0 | 3 | 4 | 7.14 | .375 | 1.78 | 11.0 | 5.3 | 10.8 | 46.2 | 56 | 39 | 37 | 9 | 27 | 55 | 0 | 5 | 3 | 0 | 0 | 1 | 4 | 4.98 |