| SP | Guthrie, J.Guthrie, Jeremy >> | 31 | 2010 | R | 65 | 33 | 33 | 9 | 14 | 4.53 | .315 | 1.35 | 9.3 | 2.9 | 5.7 | 210.2 | 218 | 110 | 106 | 23 | 67 | 132 | 3 | 0 | 0 | 2 | 18 | 5 | 3 | 4.20 |
| SP | Braden, D.Braden, Dallas # >> | 27 | 2010 | L | 63 | 32 | 32 | 12 | 9 | 4.55 | .302 | 1.28 | 9.5 | 2.0 | 6.0 | 200.0 | 212 | 107 | 101 | 26 | 44 | 133 | 2 | 0 | 0 | 0 | 17 | 3 | 3 | 4.07 |
| SP | Pettitte, A.Pettitte, Andy >> | 38 | 2010 | L | 47 | 32 | 32 | 11 | 12 | 5.69 | .359 | 1.68 | 11.5 | 3.7 | 7.7 | 172.1 | 219 | 110 | 109 | 24 | 70 | 148 | 0 | 0 | 0 | 0 | 14 | 1 | 5 | 4.33 |
| SP | Gallardo, Y.Gallardo, Yovani >> | 24 | 2010 | R | 34 | 31 | 31 | 8 | 7 | 4.58 | .342 | 1.55 | 9.3 | 4.6 | 9.4 | 155.1 | 161 | 80 | 79 | 13 | 79 | 162 | 0 | 0 | 0 | 0 | 4 | 2 | 4 | 3.57 |
| RP | Feliz, N.Feliz, Neftali >> | 22 | 2010 | R | 92 | 92 | 0 | 7 | 6 | 3.89 | .296 | 1.24 | 8.1 | 3.1 | 7.7 | 136.2 | 122 | 60 | 59 | 9 | 47 | 116 | 0 | 12 | 5 | 0 | 0 | 3 | 3 | 3.26 |
| RP | Valverde, J.Valverde, Jose >> | 31 | 2010 | R | 67 | 84 | 0 | 7 | 4 | 4.70 | .361 | 1.68 | 9.4 | 5.8 | 9.9 | 99.2 | 103 | 54 | 52 | 13 | 64 | 109 | 0 | 8 | 7 | 0 | 0 | 2 | 10 | 4.51 |
| RP | Lyon, B.Lyon, Brandon † >> | 31 | 2010 | R | 30 | 70 | 0 | 8 | 2 | 3.21 | .293 | 1.23 | 7.6 | 3.5 | 6.1 | 87.0 | 73 | 32 | 31 | 9 | 34 | 59 | 0 | 9 | 5 | 0 | 0 | 1 | 6 | 4.20 |
| RP | Hernandez, D.Hernandez, David >> | 25 | 2010 | R | 14 | 46 | 0 | 3 | 5 | 5.50 | .333 | 1.50 | 8.5 | 5.0 | 5.3 | 54.0 | 51 | 33 | 33 | 10 | 30 | 32 | 0 | 6 | 3 | 0 | 0 | 0 | 5 | 5.89 |