| SP | Hernandez, F.Hernandez, Felix >> | 24 | 2010 | R | 99 | 21 | 21 | 5 | 11 | 4.34 | .313 | 1.35 | 9.2 | 3.0 | 6.7 | 149.1 | 153 | 81 | 72 | 21 | 49 | 111 | 3 | 0 | 0 | 1 | 11 | 2 | 5 | 4.37 |
| SP | Billingsley, C.Billingsley, Chad >> | 26 | 2010 | R | 52 | 20 | 20 | 4 | 6 | 5.25 | .350 | 1.58 | 10.9 | 3.4 | 7.0 | 118.1 | 143 | 73 | 69 | 17 | 44 | 92 | 0 | 0 | 0 | 0 | 8 | 4 | 5 | 4.53 |
| SP | Pettitte, A.Pettitte, Andy # >> | 38 | 2010 | L | 47 | 20 | 20 | 6 | 4 | 4.13 | .304 | 1.29 | 9.1 | 2.4 | 6.2 | 133.0 | 135 | 65 | 61 | 21 | 36 | 91 | 0 | 0 | 0 | 0 | 11 | 3 | 1 | 4.56 |
| RP | Mujica, E.Mujica, Edward >> | 26 | 2010 | R | 74 | 53 | 0 | 6 | 1 | 4.02 | .306 | 1.32 | 9.7 | 2.2 | 8.2 | 65.0 | 70 | 29 | 29 | 11 | 16 | 59 | 0 | 6 | 1 | 0 | 0 | 0 | 1 | 4.12 |
| RP | Lopez, W.Lopez, Wilton >> | 26 | 2010 | R | 42 | 44 | 0 | 9 | 1 | 4.75 | .338 | 1.49 | 11.0 | 2.4 | 5.9 | 53.0 | 65 | 28 | 28 | 5 | 14 | 35 | 0 | 4 | 2 | 0 | 0 | 2 | 1 | 3.81 |
| RP | Duensing, B.Duensing, Brian >> | 27 | 2010 | L | 31 | 41 | 0 | 4 | 2 | 1.86 | .273 | 1.09 | 7.8 | 2.0 | 5.8 | 53.1 | 46 | 11 | 11 | 1 | 12 | 34 | 0 | 10 | 1 | 0 | 0 | 2 | 0 | 2.75 |
| SP | Matsuzaka, D.Matsuzaka, Daisuke >> | 30 | 2010 | R | 37 | 2 | 0 | 1 | 0 | 0.00 | .267 | 1.09 | 3.0 | 9.0 | 0.0 | 3.2 | 1 | 0 | 0 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 6.00 |
| SP | McDonald, J.McDonald, James >> | 26 | 2010 | R | 26 | 15 | 0 | 1 | 5 | 6.08 | .375 | 1.80 | 11.4 | 5.2 | 9.0 | 26.2 | 33 | 18 | 18 | 2 | 15 | 26 | 0 | 4 | 1 | 0 | 0 | 0 | 2 | 3.73 |