| SP | Hernandez, F.Hernandez, Felix † # >> | 24 | 2010 | R | 99 | 38 | 38 | 21 | 11 | 3.50 | .297 | 1.26 | 8.7 | 2.6 | 8.0 | 278.0 | 270 | 115 | 108 | 25 | 79 | 246 | 5 | 0 | 0 | 1 | 24 | 4 | 8 | 3.29 |
| SP | Sanchez, J.Sanchez, Jonathan >> | 28 | 2010 | L | 82 | 36 | 36 | 12 | 10 | 3.19 | .306 | 1.31 | 7.4 | 4.5 | 10.1 | 186.1 | 152 | 69 | 66 | 16 | 92 | 208 | 0 | 0 | 0 | 0 | 8 | 3 | 8 | 3.41 |
| SP | Liriano, F.Liriano, Francisco >> | 27 | 2010 | L | 56 | 35 | 35 | 13 | 10 | 7.07 | .387 | 1.86 | 12.3 | 4.5 | 9.0 | 191.0 | 260 | 155 | 150 | 19 | 95 | 191 | 0 | 0 | 0 | 0 | 10 | 7 | 23 | 3.90 |
| SP | Gonzalez, G.Gonzalez, Gio >> | 25 | 2010 | L | 55 | 34 | 34 | 8 | 12 | 5.01 | .349 | 1.58 | 9.5 | 4.8 | 7.6 | 188.2 | 199 | 109 | 105 | 32 | 100 | 158 | 0 | 0 | 0 | 0 | 12 | 5 | 3 | 5.21 |
| SP | Rodriguez, W.Rodriguez, Wandy >> | 31 | 2010 | L | 45 | 31 | 31 | 15 | 7 | 4.17 | .312 | 1.36 | 9.3 | 3.0 | 9.5 | 183.2 | 189 | 94 | 85 | 26 | 60 | 193 | 1 | 0 | 0 | 0 | 16 | 1 | 1 | 3.74 |
| RP | Gregerson, L.Gregerson, Luke >> | 26 | 2010 | R | 97 | 89 | 0 | 6 | 3 | 2.91 | .273 | 1.12 | 7.6 | 2.5 | 9.2 | 142.1 | 120 | 54 | 46 | 11 | 39 | 145 | 0 | 8 | 4 | 0 | 0 | 1 | 0 | 2.81 |
| RP | Franklin, R.Franklin, Ryan # >> | 37 | 2010 | R | 55 | 87 | 0 | 11 | 5 | 5.13 | .347 | 1.59 | 11.1 | 3.3 | 7.9 | 105.1 | 129 | 63 | 60 | 15 | 38 | 92 | 0 | 10 | 1 | 0 | 0 | 1 | 6 | 4.22 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 30 | 2010 | R | 38 | 74 | 0 | 2 | 5 | 5.10 | .360 | 1.67 | 10.6 | 4.5 | 10.1 | 84.2 | 99 | 60 | 48 | 10 | 42 | 94 | 0 | 11 | 3 | 0 | 0 | 2 | 3 | 3.88 |
| SP | Vargas, J.Vargas, Jason >> | 27 | 2010 | L | 42 | 43 | 0 | 5 | 3 | 5.74 | .382 | 1.84 | 11.3 | 5.2 | 5.3 | 69.0 | 87 | 50 | 44 | 13 | 40 | 41 | 0 | 4 | 3 | 0 | 0 | 1 | 1 | 6.04 |