| SP | Hernandez, F.Hernandez, Felix # >> | 24 | 2010 | R | 99 | 9 | 9 | 5 | 3 | 4.66 | .313 | 1.37 | 10.7 | 1.7 | 8.0 | 63.2 | 75 | 33 | 33 | 7 | 12 | 56 | 0 | 0 | 0 | 0 | 5 | 0 | 1 | 3.24 |
| SP | Sanchez, J.Sanchez, Jonathan >> | 28 | 2010 | L | 82 | 9 | 9 | 2 | 3 | 4.50 | .323 | 1.39 | 7.6 | 4.9 | 10.2 | 44.0 | 37 | 23 | 22 | 7 | 24 | 50 | 0 | 0 | 0 | 0 | 0 | 2 | 1 | 4.57 |
| SP | Liriano, F.Liriano, Francisco >> | 27 | 2010 | L | 56 | 8 | 8 | 3 | 1 | 6.11 | .380 | 1.77 | 11.4 | 4.8 | 9.2 | 45.2 | 57 | 31 | 31 | 3 | 24 | 46 | 0 | 0 | 0 | 0 | 4 | 3 | 4 | 3.62 |
| SP | Gonzalez, G.Gonzalez, Gio >> | 25 | 2010 | L | 55 | 8 | 8 | 1 | 3 | 5.01 | .336 | 1.46 | 9.2 | 4.1 | 7.4 | 46.2 | 47 | 26 | 26 | 5 | 21 | 38 | 0 | 0 | 0 | 0 | 2 | 3 | 2 | 4.33 |
| SP | Rodriguez, W.Rodriguez, Wandy >> | 31 | 2010 | L | 45 | 8 | 8 | 4 | 3 | 3.06 | .302 | 1.28 | 9.0 | 2.5 | 10.1 | 47.0 | 47 | 17 | 16 | 3 | 13 | 53 | 0 | 0 | 0 | 0 | 5 | 1 | 0 | 2.47 |
| RP | Gregerson, L.Gregerson, Luke >> | 26 | 2010 | R | 97 | 24 | 0 | 0 | 0 | 2.50 | .250 | 1.00 | 6.0 | 3.0 | 11.3 | 36.0 | 24 | 10 | 10 | 1 | 12 | 45 | 0 | 4 | 0 | 0 | 0 | 0 | 0 | 1.86 |
| RP | Franklin, R.Franklin, Ryan >> | 37 | 2010 | R | 55 | 23 | 0 | 4 | 0 | 6.51 | .376 | 1.81 | 12.0 | 4.7 | 8.7 | 27.2 | 36 | 20 | 20 | 3 | 14 | 26 | 0 | 1 | 1 | 0 | 0 | 0 | 2 | 4.07 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 30 | 2010 | R | 38 | 18 | 0 | 0 | 1 | 5.30 | .462 | 2.57 | 17.5 | 6.5 | 12.5 | 18.2 | 35 | 17 | 11 | 2 | 13 | 25 | 0 | 3 | 1 | 0 | 0 | 0 | 1 | 3.83 |
| SP | Vargas, J.Vargas, Jason >> | 27 | 2010 | L | 42 | 12 | 0 | 2 | 1 | 4.58 | .330 | 1.47 | 9.5 | 4.3 | 2.8 | 19.2 | 20 | 10 | 10 | 2 | 9 | 6 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 5.16 |