| SP | Scherzer, M.Scherzer, Max >> | 26 | 2010 | R | 61 | 20 | 20 | 8 | 7 | 4.76 | .333 | 1.49 | 8.9 | 4.5 | 8.6 | 121.0 | 119 | 69 | 64 | 14 | 61 | 116 | 0 | 0 | 0 | 0 | 10 | 1 | 3 | 4.12 |
| SP | Weaver, J.Weaver, Jered † >> | 28 | 2010 | R | 96 | 21 | 21 | 10 | 7 | 3.32 | .288 | 1.19 | 8.1 | 2.7 | 9.3 | 151.2 | 136 | 57 | 56 | 13 | 45 | 156 | 2 | 0 | 0 | 0 | 13 | 3 | 4 | 3.01 |
| SP | Cahill, T.Cahill, Trevor # >> | 22 | 2010 | R | 84 | 20 | 20 | 8 | 10 | 5.05 | .310 | 1.31 | 9.6 | 2.2 | 6.5 | 128.1 | 137 | 72 | 72 | 14 | 31 | 93 | 3 | 0 | 0 | 0 | 9 | 5 | 2 | 3.81 |
| RP | Valverde, J.Valverde, Jose >> | 31 | 2010 | R | 67 | 47 | 0 | 4 | 2 | 2.49 | .293 | 1.24 | 7.7 | 3.6 | 10.3 | 50.2 | 43 | 14 | 14 | 2 | 20 | 57 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 2.44 |
| RP | Sanches, B.Sanches, Brian >> | 32 | 2010 | R | 65 | 35 | 0 | 1 | 1 | 3.11 | .315 | 1.35 | 8.8 | 3.6 | 8.3 | 37.2 | 36 | 13 | 13 | 8 | 15 | 34 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 5.27 |
| RP | Aardsma, D.Aardsma, David >> | 29 | 2010 | R | 63 | 11 | 0 | 1 | 0 | 0.71 | .224 | 0.79 | 5.3 | 2.3 | 6.0 | 12.2 | 7 | 1 | 1 | 0 | 3 | 8 | 0 | 0 | 0 | 0 | 0 | 1 | 2 | 2.67 |
| RP | Marshall, S.Marshall, Sean >> | 28 | 2010 | L | 60 | 19 | 0 | 2 | 1 | 5.24 | .330 | 1.48 | 10.2 | 3.3 | 8.2 | 22.1 | 25 | 15 | 13 | 0 | 8 | 20 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2.27 |
| SP | Niemann, J.Niemann, Jeff >> | 27 | 2010 | R | 57 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| CL | Rivera, M.Rivera, Mariano † >> | 41 | 2010 | R | 91 | 38 | 0 | 2 | 3 | 1.13 | .273 | 1.05 | 6.3 | 3.2 | 5.6 | 40.0 | 28 | 5 | 5 | 2 | 14 | 25 | 0 | 28 | 1 | 0 | 0 | 3 | 0 | 3.68 |
| SP | Dickey, R.Dickey, R.A. >> | 36 | 2010 | R | 58 | 16 | 4 | 4 | 1 | 5.25 | .336 | 1.49 | 10.5 | 3.1 | 6.3 | 73.2 | 85 | 45 | 43 | 9 | 25 | 51 | 0 | 0 | 0 | 0 | 3 | 2 | 4 | 4.32 |
| SU | Madson, R.Madson, Ryan >> | 30 | 2010 | R | 75 | 31 | 0 | 0 | 1 | 3.25 | .325 | 1.45 | 9.0 | 4.3 | 10.0 | 27.2 | 27 | 10 | 10 | 3 | 13 | 30 | 0 | 3 | 2 | 0 | 0 | 0 | 2 | 3.67 |