| SP | Hudson, D.Hudson, Daniel † # >> | 23 | 2010 | R | 100 | 34 | 34 | 19 | 8 | 4.32 | .304 | 1.30 | 8.8 | 2.9 | 7.1 | 221.0 | 217 | 109 | 106 | 23 | 70 | 174 | 1 | 0 | 0 | 1 | 22 | 3 | 8 | 3.77 |
| SP | Hellickson, J.Hellickson, Jeremy >> | 23 | 2010 | R | 83 | 33 | 33 | 0 | 10 | 4.45 | .308 | 1.33 | 9.4 | 2.6 | 8.5 | 117.1 | 122 | 60 | 58 | 14 | 34 | 110 | 0 | 0 | 0 | 0 | 0 | 1 | 3 | 3.57 |
| SP | Buchholz, C.Buchholz, Clay >> | 26 | 2010 | R | 69 | 32 | 32 | 8 | 17 | 4.87 | .323 | 1.40 | 9.1 | 3.5 | 5.3 | 197.2 | 200 | 109 | 107 | 24 | 76 | 117 | 0 | 0 | 0 | 0 | 15 | 7 | 4 | 4.66 |
| SP | Scherzer, M.Scherzer, Max >> | 26 | 2010 | R | 61 | 33 | 32 | 11 | 15 | 4.59 | .320 | 1.40 | 9.0 | 3.6 | 7.5 | 200.0 | 199 | 108 | 102 | 22 | 81 | 167 | 1 | 0 | 0 | 0 | 15 | 2 | 1 | 4.01 |
| SP | Garland, J.Garland, Jon >> | 31 | 2010 | R | 46 | 32 | 31 | 11 | 16 | 5.15 | .358 | 1.66 | 10.3 | 4.6 | 6.6 | 190.1 | 218 | 121 | 109 | 23 | 98 | 139 | 0 | 0 | 0 | 0 | 11 | 3 | 4 | 4.71 |
| CL | Soriano, R.Soriano, Rafael † >> | 31 | 2010 | R | 93 | 63 | 0 | 4 | 9 | 3.94 | .304 | 1.28 | 8.0 | 3.5 | 6.6 | 64.0 | 57 | 31 | 28 | 7 | 25 | 47 | 0 | 40 | 4 | 0 | 0 | 2 | 0 | 4.22 |
| RP | Betancourt, R.Betancourt, Rafael >> | 35 | 2010 | R | 79 | 91 | 0 | 11 | 4 | 4.60 | .316 | 1.39 | 9.8 | 2.7 | 9.5 | 123.1 | 134 | 67 | 63 | 15 | 37 | 130 | 0 | 2 | 6 | 0 | 0 | 0 | 11 | 3.37 |
| RP | Soria, J.Soria, Joakim >> | 26 | 2010 | R | 69 | 85 | 0 | 3 | 1 | 3.91 | .269 | 1.09 | 7.4 | 2.3 | 8.0 | 115.0 | 95 | 50 | 50 | 15 | 30 | 102 | 0 | 4 | 2 | 0 | 0 | 2 | 2 | 3.76 |
| RP | Sanches, B.Sanches, Brian >> | 32 | 2010 | R | 65 | 68 | 0 | 1 | 4 | 4.23 | .345 | 1.54 | 9.1 | 4.9 | 7.5 | 76.2 | 77 | 44 | 36 | 12 | 41 | 63 | 0 | 2 | 4 | 0 | 0 | 3 | 6 | 5.13 |
| RP | Takahashi, H.Takahashi, Hisanori >> | 35 | 2010 | L | 21 | 50 | 0 | 1 | 3 | 4.79 | .354 | 1.61 | 11.0 | 3.6 | 6.3 | 67.2 | 82 | 38 | 36 | 11 | 27 | 47 | 0 | 1 | 2 | 0 | 0 | 2 | 2 | 5.03 |
| RP | Fuentes, B.Fuentes, Brian # >> | 35 | 2010 | L | 83 | 44 | 0 | 4 | 2 | 6.10 | .340 | 1.53 | 10.2 | 3.7 | 7.2 | 51.2 | 58 | 38 | 35 | 5 | 21 | 41 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 3.96 |