| SP | Strasburg, S.Strasburg, Stephen >> | 21 | 2010 | R | 97 | 22 | 22 | 8 | 4 | 4.36 | .330 | 1.45 | 9.4 | 3.8 | 10.6 | 115.2 | 120 | 60 | 56 | 13 | 48 | 135 | 0 | 0 | 0 | 0 | 6 | 3 | 4 | 3.45 |
| SP | Kershaw, C.Kershaw, Clayton † $ >> | 22 | 2010 | L | 88 | 20 | 20 | 12 | 4 | 3.45 | .285 | 1.18 | 7.8 | 2.9 | 9.3 | 127.2 | 110 | 49 | 49 | 5 | 41 | 131 | 0 | 0 | 0 | 0 | 13 | 2 | 3 | 2.46 |
| SP | Kuroda, H.Kuroda, Hiroki >> | 35 | 2010 | R | 71 | 20 | 20 | 5 | 9 | 5.31 | .348 | 1.56 | 10.9 | 3.2 | 7.5 | 117.0 | 142 | 76 | 69 | 14 | 41 | 97 | 0 | 0 | 0 | 0 | 7 | 4 | 4 | 4.05 |
| SP | Guthrie, J.Guthrie, Jeremy # >> | 31 | 2010 | R | 65 | 20 | 20 | 10 | 5 | 4.77 | .321 | 1.42 | 10.0 | 2.8 | 4.6 | 126.1 | 140 | 68 | 67 | 22 | 39 | 64 | 1 | 0 | 0 | 1 | 8 | 0 | 0 | 5.18 |
| SP | Lincecum, T.Lincecum, Tim >> | 26 | 2010 | R | 59 | 21 | 20 | 6 | 9 | 4.73 | .338 | 1.52 | 9.2 | 4.4 | 8.3 | 118.0 | 121 | 65 | 62 | 13 | 58 | 109 | 0 | 0 | 0 | 0 | 11 | 2 | 2 | 4.11 |
| RP | Wagner, B.Wagner, Billy >> | 39 | 2010 | L | 98 | 57 | 0 | 3 | 3 | 3.81 | .290 | 1.22 | 7.2 | 3.8 | 8.0 | 85.0 | 68 | 39 | 36 | 3 | 36 | 76 | 0 | 3 | 4 | 0 | 0 | 0 | 1 | 2.94 |
| RP | Hensley, C.Hensley, Clay >> | 31 | 2010 | R | 68 | 42 | 0 | 3 | 1 | 2.92 | .299 | 1.28 | 7.8 | 3.8 | 9.9 | 52.1 | 45 | 20 | 17 | 2 | 22 | 57 | 0 | 2 | 1 | 0 | 0 | 0 | 1 | 2.58 |
| RP | Balfour, G.Balfour, Grant >> | 33 | 2010 | R | 62 | 39 | 0 | 5 | 2 | 2.40 | .282 | 1.16 | 7.0 | 3.4 | 9.6 | 45.0 | 35 | 12 | 12 | 3 | 17 | 48 | 0 | 8 | 2 | 0 | 0 | 1 | 2 | 2.93 |
| RP | Clippard, T.Clippard, Tyler >> | 25 | 2010 | R | 50 | 23 | 0 | 1 | 3 | 4.81 | .371 | 1.77 | 12.0 | 4.1 | 9.8 | 24.1 | 32 | 13 | 13 | 3 | 11 | 26 | 0 | 4 | 0 | 0 | 0 | 0 | 0 | 3.83 |
| RP | Uehara, K.Uehara, Koji >> | 35 | 2010 | R | 81 | 26 | 0 | 0 | 1 | 3.00 | .286 | 1.17 | 9.3 | 1.2 | 9.9 | 30.0 | 31 | 12 | 10 | 5 | 4 | 33 | 0 | 2 | 0 | 0 | 0 | 1 | 0 | 3.47 |