| SP | Oswalt, R.Oswalt, Roy $ >> | 33 | 2010 | R | 100 | 37 | 37 | 14 | 12 | 3.29 | .301 | 1.26 | 8.4 | 2.9 | 7.3 | 232.2 | 216 | 96 | 85 | 17 | 76 | 187 | 0 | 0 | 0 | 0 | 22 | 8 | 3 | 3.43 |
| SP | Hudson, T.Hudson, Tim # >> | 35 | 2010 | R | 79 | 33 | 33 | 17 | 7 | 3.47 | .297 | 1.26 | 8.7 | 2.6 | 7.1 | 202.1 | 195 | 86 | 78 | 16 | 59 | 160 | 2 | 0 | 0 | 2 | 19 | 2 | 4 | 3.35 |
| SP | Lewis, C.Lewis, Colby # >> | 31 | 2010 | R | 77 | 33 | 33 | 12 | 8 | 4.86 | .317 | 1.38 | 9.6 | 2.9 | 7.7 | 196.1 | 208 | 111 | 106 | 31 | 63 | 167 | 0 | 0 | 0 | 0 | 14 | 3 | 2 | 4.36 |
| SP | Kuroda, H.Kuroda, Hiroki >> | 35 | 2010 | R | 71 | 31 | 31 | 12 | 10 | 6.35 | .366 | 1.69 | 12.1 | 3.1 | 7.2 | 173.0 | 233 | 126 | 122 | 26 | 60 | 138 | 0 | 0 | 0 | 0 | 11 | 6 | 8 | 4.50 |
| RP | Bailey, A.Bailey, Andrew >> | 26 | 2010 | R | 85 | 84 | 0 | 7 | 2 | 2.96 | .287 | 1.18 | 7.1 | 3.5 | 6.6 | 100.1 | 79 | 33 | 33 | 8 | 39 | 73 | 0 | 2 | 5 | 0 | 0 | 3 | 0 | 3.84 |
| RP | Axford, J.Axford, John >> | 27 | 2010 | R | 64 | 40 | 0 | 4 | 2 | 3.45 | .314 | 1.33 | 6.8 | 5.3 | 10.2 | 44.1 | 33 | 18 | 17 | 0 | 26 | 50 | 0 | 2 | 2 | 0 | 0 | 2 | 5 | 2.64 |
| RP | Clippard, T.Clippard, Tyler >> | 25 | 2010 | R | 50 | 34 | 0 | 1 | 0 | 4.36 | .293 | 1.22 | 7.7 | 3.3 | 9.0 | 43.1 | 37 | 23 | 21 | 8 | 16 | 43 | 0 | 0 | 0 | 0 | 0 | 1 | 3 | 4.60 |
| SP | Sabathia, C.Sabathia, CC >> | 30 | 2010 | L | 70 | 9 | 0 | 4 | 0 | 9.82 | .450 | 2.45 | 13.9 | 8.2 | 6.5 | 11.0 | 17 | 12 | 12 | 2 | 10 | 8 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 6.64 |
| CL | Benoit, J.Benoit, Joaquin $ >> | 33 | 2010 | R | 100 | 69 | 0 | 6 | 4 | 3.00 | .283 | 1.12 | 7.8 | 2.3 | 10.0 | 75.0 | 65 | 28 | 25 | 9 | 19 | 83 | 0 | 40 | 6 | 0 | 0 | 5 | 2 | 3.31 |