| SP | Strasburg, S.Strasburg, Stephen >> | 21 | 2010 | R | 97 | 6 | 6 | 4 | 1 | 1.47 | .241 | 0.93 | 5.5 | 3.0 | 8.0 | 36.2 | 22 | 6 | 6 | 1 | 12 | 32 | 0 | 0 | 0 | 0 | 4 | 1 | 0 | 2.67 |
| SP | Kershaw, C.Kershaw, Clayton >> | 22 | 2010 | L | 88 | 5 | 5 | 2 | 0 | 3.12 | .311 | 1.36 | 7.4 | 5.0 | 6.9 | 34.2 | 28 | 12 | 12 | 1 | 19 | 26 | 1 | 0 | 0 | 1 | 4 | 0 | 0 | 3.53 |
| SP | Kuroda, H.Kuroda, Hiroki >> | 35 | 2010 | R | 71 | 5 | 5 | 1 | 3 | 7.52 | .368 | 1.75 | 12.5 | 3.5 | 8.0 | 26.1 | 36 | 24 | 22 | 7 | 10 | 23 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 5.88 |
| SP | Scherzer, M.Scherzer, Max >> | 26 | 2010 | R | 61 | 8 | 4 | 4 | 2 | 6.47 | .356 | 1.56 | 11.3 | 2.8 | 6.5 | 32.0 | 40 | 23 | 23 | 7 | 10 | 23 | 0 | 0 | 0 | 0 | 1 | 3 | 3 | 5.63 |
| RP | Thornton, M.Thornton, Matt >> | 34 | 2010 | L | 89 | 15 | 0 | 1 | 0 | 2.87 | .299 | 1.21 | 8.4 | 3.0 | 9.6 | 15.2 | 14 | 5 | 5 | 1 | 5 | 16 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 2.93 |
| RP | Uehara, K.Uehara, Koji >> | 35 | 2010 | R | 81 | 16 | 0 | 1 | 0 | 3.52 | .207 | 0.72 | 6.0 | 0.6 | 12.0 | 15.1 | 10 | 6 | 6 | 1 | 1 | 20 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1.60 |
| RP | Marmol, C.Marmol, Carlos >> | 28 | 2010 | R | 70 | 11 | 0 | 0 | 1 | 5.54 | .316 | 1.38 | 6.9 | 5.5 | 16.6 | 13.0 | 10 | 8 | 8 | 2 | 8 | 24 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 3.15 |
| RP | Ogando, A.Ogando, Alexi >> | 26 | 2010 | R | 57 | 10 | 0 | 0 | 0 | 14.40 | .483 | 2.80 | 18.9 | 6.3 | 13.5 | 10.0 | 21 | 16 | 16 | 2 | 7 | 15 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 4.70 |
| RP | Burnett, S.Burnett, Sean >> | 28 | 2010 | L | 46 | 17 | 0 | 0 | 1 | 2.84 | .367 | 1.66 | 10.5 | 5.3 | 7.5 | 12.2 | 14 | 4 | 4 | 1 | 7 | 10 | 0 | 1 | 2 | 0 | 0 | 1 | 1 | 4.42 |
| RP | Belisle, M.Belisle, Matt >> | 30 | 2010 | R | 45 | 4 | 0 | 1 | 0 | 0.00 | .385 | 1.88 | 22.5 | 0.0 | 9.0 | 2.2 | 5 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1.00 |