| SP | Wainwright, A.Wainwright, Adam >> | 29 | 2010 | R | 98 | 34 | 34 | 12 | 13 | 2.74 | .270 | 1.08 | 7.5 | 2.2 | 7.1 | 233.0 | 194 | 77 | 71 | 21 | 57 | 183 | 2 | 0 | 0 | 0 | 27 | 7 | 1 | 3.42 |
| SP | Verlander, J.Verlander, Justin >> | 27 | 2010 | R | 81 | 33 | 33 | 10 | 14 | 3.92 | .336 | 1.49 | 9.5 | 4.0 | 8.7 | 199.2 | 210 | 102 | 87 | 19 | 88 | 192 | 0 | 0 | 0 | 0 | 15 | 5 | 8 | 3.71 |
| SP | Kennedy, I.Kennedy, Ian >> | 26 | 2010 | R | 72 | 32 | 32 | 9 | 18 | 4.91 | .322 | 1.39 | 8.8 | 3.8 | 6.6 | 192.1 | 188 | 118 | 105 | 31 | 80 | 140 | 1 | 0 | 0 | 0 | 16 | 6 | 5 | 4.98 |
| SP | Anderson, B.Anderson, Brett >> | 22 | 2010 | L | 51 | 32 | 32 | 2 | 13 | 3.93 | .317 | 1.37 | 9.9 | 2.4 | 6.8 | 165.0 | 182 | 84 | 72 | 18 | 44 | 124 | 0 | 0 | 0 | 0 | 9 | 4 | 0 | 3.79 |
| SP | Santana, J.Santana, Johan >> | 31 | 2010 | L | 66 | 33 | 31 | 13 | 14 | 3.68 | .296 | 1.23 | 8.7 | 2.4 | 6.3 | 205.2 | 198 | 100 | 84 | 21 | 54 | 144 | 1 | 0 | 0 | 1 | 17 | 8 | 4 | 3.83 |
| RP | Wagner, B.Wagner, Billy >> | 39 | 2010 | L | 98 | 114 | 0 | 2 | 3 | 3.01 | .280 | 1.10 | 6.7 | 3.3 | 9.7 | 92.2 | 68 | 34 | 31 | 3 | 34 | 99 | 0 | 5 | 2 | 0 | 0 | 6 | 0 | 2.58 |
| RP | Casilla, S.Casilla, Santiago >> | 30 | 2010 | R | 54 | 93 | 0 | 4 | 3 | 3.43 | .330 | 1.46 | 6.9 | 6.3 | 8.4 | 81.1 | 62 | 38 | 31 | 3 | 57 | 76 | 0 | 7 | 4 | 0 | 0 | 1 | 11 | 3.75 |
| RP | Marshall, S.Marshall, Sean >> | 28 | 2010 | L | 60 | 65 | 0 | 5 | 5 | 6.33 | .360 | 1.64 | 10.1 | 4.6 | 10.7 | 64.0 | 72 | 48 | 45 | 5 | 33 | 76 | 0 | 4 | 3 | 0 | 0 | 3 | 2 | 3.33 |