| SP | Verlander, J.Verlander, Justin >> | 27 | 2010 | R | 81 | 21 | 21 | 6 | 9 | 5.08 | .354 | 1.63 | 11.0 | 3.7 | 7.8 | 118.2 | 144 | 70 | 67 | 16 | 49 | 102 | 0 | 0 | 0 | 0 | 10 | 2 | 7 | 4.33 |
| SP | Hamels, C.Hamels, Cole >> | 27 | 2010 | L | 76 | 20 | 20 | 2 | 7 | 5.95 | .365 | 1.70 | 11.7 | 3.6 | 8.7 | 107.1 | 139 | 72 | 71 | 14 | 43 | 104 | 0 | 0 | 0 | 0 | 7 | 3 | 0 | 4.05 |
| SP | Chacin, J.Chacin, Jhoulys >> | 22 | 2010 | R | 64 | 20 | 20 | 2 | 8 | 4.99 | .343 | 1.56 | 9.0 | 5.1 | 9.9 | 79.1 | 79 | 46 | 44 | 10 | 45 | 87 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 4.15 |
| SP | Gallardo, Y.Gallardo, Yovani >> | 24 | 2010 | R | 34 | 24 | 20 | 2 | 12 | 6.02 | .364 | 1.71 | 11.3 | 4.2 | 8.8 | 107.2 | 134 | 75 | 72 | 10 | 50 | 105 | 0 | 0 | 0 | 0 | 3 | 1 | 2 | 3.68 |
| RP | Feliz, N.Feliz, Neftali >> | 22 | 2010 | R | 92 | 68 | 0 | 6 | 6 | 3.84 | .328 | 1.43 | 8.4 | 4.6 | 10.8 | 86.2 | 80 | 37 | 37 | 9 | 44 | 103 | 0 | 3 | 1 | 0 | 0 | 3 | 3 | 3.60 |
| RP | Soria, J.Soria, Joakim >> | 26 | 2010 | R | 69 | 62 | 0 | 5 | 4 | 3.56 | .285 | 1.19 | 8.8 | 1.9 | 9.7 | 81.0 | 79 | 34 | 32 | 10 | 17 | 87 | 0 | 4 | 4 | 0 | 0 | 1 | 2 | 3.12 |
| RP | Axford, J.Axford, John >> | 27 | 2010 | R | 64 | 50 | 0 | 1 | 4 | 5.06 | .374 | 1.76 | 9.3 | 6.7 | 7.9 | 58.2 | 60 | 36 | 33 | 9 | 43 | 51 | 0 | 3 | 4 | 0 | 0 | 2 | 6 | 5.59 |