| SP | Hernandez, F.Hernandez, Felix # >> | 24 | 2010 | R | 99 | 5 | 5 | 0 | 3 | 5.05 | .318 | 1.40 | 9.5 | 3.3 | 6.2 | 35.2 | 37 | 21 | 20 | 5 | 13 | 24 | 1 | 0 | 0 | 0 | 1 | 0 | 2 | 4.60 |
| SP | Verlander, J.Verlander, Justin >> | 27 | 2010 | R | 81 | 5 | 5 | 1 | 3 | 7.62 | .397 | 1.98 | 12.2 | 5.8 | 7.1 | 28.1 | 38 | 24 | 24 | 7 | 18 | 22 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 6.61 |
| SP | Marcum, S.Marcum, Shaun >> | 29 | 2010 | R | 73 | 5 | 5 | 2 | 2 | 6.82 | .367 | 1.71 | 12.5 | 3.2 | 4.9 | 31.2 | 43 | 24 | 24 | 6 | 11 | 17 | 0 | 0 | 0 | 0 | 2 | 1 | 0 | 5.58 |
| SP | Guthrie, J.Guthrie, Jeremy >> | 31 | 2010 | R | 65 | 4 | 4 | 2 | 0 | 1.63 | .308 | 1.30 | 8.3 | 3.7 | 4.7 | 27.2 | 25 | 5 | 5 | 0 | 11 | 14 | 0 | 0 | 0 | 0 | 4 | 1 | 0 | 3.30 |
| SP | Anderson, B.Anderson, Brett >> | 22 | 2010 | L | 51 | 4 | 4 | 3 | 0 | 1.88 | .217 | 0.83 | 5.6 | 1.9 | 4.9 | 24.0 | 15 | 6 | 5 | 1 | 5 | 13 | 0 | 0 | 0 | 0 | 3 | 0 | 0 | 3.08 |
| CL | Peralta, J.Peralta, Joel >> | 34 | 2010 | R | 95 | 13 | 0 | 0 | 2 | 3.55 | .321 | 1.42 | 9.8 | 3.8 | 9.0 | 12.2 | 13 | 5 | 5 | 3 | 5 | 12 | 0 | 3 | 1 | 0 | 0 | 0 | 0 | 5.50 |
| SU | Bailey, A.Bailey, Andrew >> | 26 | 2010 | R | 85 | 7 | 0 | 1 | 0 | 2.00 | .206 | 0.78 | 5.0 | 2.0 | 9.0 | 9.0 | 5 | 2 | 2 | 1 | 2 | 9 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 3.11 |
| RP | Betancourt, R.Betancourt, Rafael >> | 35 | 2010 | R | 79 | 13 | 0 | 1 | 1 | 5.06 | .333 | 1.50 | 12.9 | 0.6 | 10.1 | 16.0 | 23 | 9 | 9 | 4 | 1 | 18 | 0 | 1 | 1 | 0 | 0 | 0 | 2 | 4.19 |
| RP | Madson, R.Madson, Ryan >> | 30 | 2010 | R | 75 | 8 | 0 | 0 | 0 | 7.45 | .310 | 1.34 | 7.0 | 6.0 | 8.0 | 9.2 | 7 | 8 | 8 | 2 | 6 | 8 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 6.11 |
| RP | Balfour, G.Balfour, Grant >> | 33 | 2010 | R | 62 | 7 | 0 | 0 | 0 | 1.08 | .286 | 1.20 | 7.9 | 3.4 | 11.3 | 8.1 | 7 | 1 | 1 | 0 | 3 | 10 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1.63 |
| RP | Guerrier, M.Guerrier, Matt >> | 32 | 2010 | R | 51 | 7 | 0 | 0 | 2 | 4.91 | .353 | 1.64 | 14.1 | 1.3 | 3.9 | 7.1 | 11 | 6 | 4 | 1 | 1 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.43 |