| SP | Skubal, T.Skubal, Tarik † >> | 28 | 2025 | L | 100 | 20 | 20 | 9 | 6 | 3.90 | .287 | 1.17 | 8.4 | 2.1 | 12.5 | 127.0 | 118 | 56 | 55 | 16 | 30 | 177 | 0 | 0 | 0 | 0 | 12 | 5 | 3 | 2.68 |
| SP | Nelson, R.Nelson, Ryne >> | 27 | 2025 | R | 79 | 19 | 19 | 5 | 6 | 4.23 | .310 | 1.31 | 8.9 | 3.0 | 7.4 | 93.2 | 92 | 44 | 44 | 13 | 31 | 76 | 0 | 0 | 0 | 0 | 5 | 3 | 1 | 4.28 |
| SP | Abbott, A.Abbott, Andrew >> | 26 | 2025 | L | 67 | 18 | 18 | 9 | 5 | 5.65 | .313 | 1.34 | 9.5 | 2.5 | 7.7 | 100.1 | 106 | 64 | 63 | 7 | 28 | 86 | 0 | 0 | 0 | 0 | 9 | 3 | 3 | 3.12 |
| SP | Taillon, J.Taillon, Jameson >> | 33 | 2025 | R | 74 | 18 | 18 | 4 | 9 | 6.70 | .364 | 1.66 | 11.8 | 3.3 | 7.9 | 88.2 | 115 | 71 | 66 | 21 | 32 | 77 | 0 | 0 | 0 | 0 | 4 | 5 | 0 | 5.61 |
| CL | Chapman, A.Chapman, Aroldis $ >> | 37 | 2025 | L | 100 | 38 | 0 | 1 | 3 | 3.79 | .280 | 1.17 | 7.7 | 2.9 | 11.3 | 40.1 | 34 | 17 | 17 | 5 | 13 | 50 | 0 | 19 | 2 | 0 | 0 | 0 | 0 | 3.10 |
| SU | Miller, S.Miller, Shelby >> | 34 | 2025 | R | 84 | 46 | 0 | 2 | 3 | 5.24 | .332 | 1.47 | 9.8 | 3.5 | 9.4 | 46.1 | 50 | 27 | 27 | 7 | 18 | 48 | 0 | 0 | 2 | 0 | 0 | 1 | 0 | 4.13 |
| RP | Saalfrank, A.Saalfrank, Andrew >> | 27 | 2025 | L | 83 | 63 | 0 | 5 | 1 | 2.17 | .227 | 0.84 | 5.4 | 2.2 | 8.8 | 58.0 | 35 | 14 | 14 | 1 | 14 | 57 | 0 | 1 | 0 | 0 | 0 | 2 | 4 | 2.09 |
| RP | Henriquez, R.Henriquez, Ronny >> | 25 | 2025 | R | 78 | 49 | 0 | 2 | 2 | 2.68 | .284 | 1.16 | 6.1 | 4.4 | 11.9 | 53.2 | 36 | 16 | 16 | 1 | 26 | 70 | 0 | 1 | 1 | 0 | 0 | 2 | 0 | 2.19 |
| RP | Santillan, T.Santillan, Tony >> | 28 | 2025 | R | 73 | 48 | 0 | 4 | 1 | 5.70 | .350 | 1.52 | 9.4 | 4.5 | 12.2 | 42.2 | 44 | 29 | 27 | 4 | 21 | 57 | 0 | 2 | 2 | 0 | 0 | 4 | 1 | 3.31 |
| SP | Springs, J.Springs, Jeffrey >> | 32 | 2025 | L | 63 | 21 | 0 | 4 | 0 | 5.46 | .345 | 1.54 | 10.4 | 3.6 | 7.9 | 57.2 | 66 | 36 | 35 | 9 | 23 | 50 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 4.61 |