| SP | Skubal, T.Skubal, Tarik >> | 28 | 2025 | L | 100 | 26 | 26 | 10 | 11 | 3.87 | .265 | 1.06 | 7.3 | 2.3 | 10.2 | 160.1 | 129 | 70 | 69 | 16 | 41 | 182 | 2 | 0 | 0 | 1 | 15 | 3 | 2 | 2.85 |
| SP | Sale, C.Sale, Chris # $ >> | 36 | 2025 | L | 83 | 25 | 25 | 11 | 7 | 3.90 | .280 | 1.13 | 7.9 | 2.2 | 10.3 | 150.0 | 132 | 65 | 65 | 12 | 37 | 171 | 1 | 0 | 0 | 1 | 14 | 6 | 2 | 2.62 |
| SP | Horton, C.Horton, Cade >> | 23 | 2025 | R | 76 | 25 | 25 | 5 | 9 | 5.80 | .361 | 1.65 | 11.3 | 3.6 | 6.9 | 111.2 | 139 | 77 | 72 | 15 | 45 | 85 | 0 | 0 | 0 | 0 | 4 | 5 | 0 | 4.58 |
| SP | Bello, B.Bello, Brayan >> | 26 | 2025 | R | 55 | 24 | 24 | 8 | 5 | 4.65 | .356 | 1.63 | 10.1 | 4.7 | 8.5 | 127.2 | 142 | 67 | 66 | 14 | 66 | 120 | 0 | 0 | 0 | 0 | 8 | 4 | 3 | 4.20 |
| RP | Speier, G.Speier, Gabe >> | 30 | 2025 | L | 96 | 74 | 0 | 2 | 3 | 2.98 | .278 | 1.12 | 8.0 | 2.2 | 11.0 | 99.2 | 88 | 33 | 33 | 10 | 24 | 121 | 0 | 7 | 3 | 0 | 0 | 3 | 0 | 2.69 |
| RP | Cleavinger, G.Cleavinger, Garrett >> | 31 | 2025 | L | 93 | 64 | 0 | 4 | 3 | 3.40 | .291 | 1.20 | 8.4 | 2.6 | 10.1 | 84.2 | 78 | 32 | 32 | 6 | 24 | 94 | 0 | 9 | 4 | 0 | 0 | 2 | 2 | 2.62 |
| RP | Keller, B.Keller, Brad $ >> | 29 | 2025 | R | 91 | 59 | 0 | 4 | 3 | 3.07 | .295 | 1.24 | 8.2 | 3.1 | 10.5 | 76.1 | 69 | 26 | 26 | 9 | 26 | 89 | 0 | 5 | 0 | 0 | 0 | 1 | 2 | 3.26 |
| RP | Bednar, D.Bednar, David >> | 30 | 2025 | R | 79 | 47 | 0 | 3 | 2 | 3.30 | .323 | 1.38 | 8.7 | 3.8 | 9.8 | 57.1 | 55 | 21 | 21 | 8 | 24 | 62 | 0 | 5 | 3 | 0 | 0 | 3 | 1 | 4.07 |
| RP | Bender, A.Bender, Anthony >> | 30 | 2025 | R | 77 | 39 | 0 | 6 | 4 | 3.65 | .299 | 1.28 | 6.6 | 5.0 | 8.6 | 49.1 | 36 | 20 | 20 | 5 | 27 | 47 | 0 | 2 | 0 | 0 | 0 | 0 | 1 | 4.06 |
| RP | Strahm, M.Strahm, Matt >> | 33 | 2025 | L | 73 | 39 | 0 | 1 | 3 | 3.61 | .302 | 1.30 | 8.4 | 3.4 | 10.5 | 42.1 | 39 | 17 | 17 | 6 | 16 | 49 | 0 | 3 | 2 | 0 | 0 | 0 | 1 | 3.67 |
| RP | Coulombe, D.Coulombe, Daniel >> | 35 | 2025 | L | 65 | 36 | 0 | 4 | 1 | 3.35 | .283 | 1.14 | 5.7 | 4.6 | 10.9 | 43.0 | 27 | 17 | 16 | 6 | 22 | 52 | 0 | 1 | 0 | 0 | 0 | 2 | 0 | 4.07 |