| SP | Skubal, T.Skubal, Tarik † >> | 28 | 2025 | L | 100 | 34 | 34 | 16 | 7 | 2.50 | .267 | 1.07 | 8.1 | 1.6 | 11.3 | 241.0 | 216 | 72 | 67 | 19 | 42 | 302 | 0 | 0 | 0 | 0 | 28 | 6 | 1 | 2.12 |
| SP | Glasnow, T.Glasnow, Tyler >> | 31 | 2025 | R | 86 | 33 | 33 | 12 | 4 | 3.07 | .314 | 1.35 | 7.5 | 4.7 | 10.1 | 175.2 | 146 | 65 | 60 | 16 | 91 | 197 | 0 | 0 | 0 | 0 | 9 | 4 | 6 | 3.57 |
| SP | Rasmussen, D.Rasmussen, Drew # >> | 29 | 2025 | R | 84 | 32 | 32 | 11 | 5 | 3.94 | .307 | 1.28 | 8.8 | 2.7 | 7.2 | 164.2 | 160 | 72 | 72 | 23 | 50 | 132 | 0 | 0 | 0 | 0 | 8 | 9 | 3 | 4.29 |
| SP | Mahle, T.Mahle, Tyler # >> | 30 | 2025 | R | 71 | 32 | 32 | 18 | 6 | 4.41 | .333 | 1.46 | 9.2 | 4.1 | 7.2 | 177.2 | 180 | 89 | 87 | 26 | 80 | 142 | 0 | 0 | 0 | 0 | 13 | 6 | 0 | 4.76 |
| SP | Woods Richardson, S.Woods Richardson, Simeon † >> | 24 | 2025 | R | 56 | 31 | 31 | 12 | 9 | 4.35 | .332 | 1.47 | 9.1 | 4.2 | 8.3 | 157.1 | 158 | 76 | 76 | 19 | 74 | 145 | 0 | 0 | 0 | 0 | 4 | 3 | 3 | 4.20 |
| RP | Morejon, A.Morejon, Adrian >> | 26 | 2025 | L | 90 | 86 | 0 | 10 | 7 | 2.67 | .275 | 1.12 | 7.6 | 2.5 | 7.8 | 118.0 | 99 | 40 | 35 | 9 | 33 | 102 | 0 | 12 | 4 | 0 | 0 | 2 | 2 | 3.15 |
| RP | Bender, A.Bender, Anthony >> | 30 | 2025 | R | 77 | 82 | 0 | 7 | 6 | 3.53 | .296 | 1.21 | 7.2 | 3.8 | 7.4 | 104.2 | 83 | 41 | 41 | 12 | 44 | 86 | 0 | 5 | 5 | 0 | 0 | 5 | 2 | 4.26 |
| RP | Holton, T.Holton, Tyler >> | 29 | 2025 | L | 63 | 74 | 0 | 6 | 3 | 3.30 | .283 | 1.15 | 8.4 | 2.0 | 6.3 | 95.1 | 89 | 36 | 35 | 10 | 21 | 66 | 0 | 13 | 3 | 0 | 0 | 3 | 2 | 3.74 |
| RP | Phillips, T.Phillips, Tyler >> | 27 | 2025 | R | 55 | 62 | 0 | 2 | 5 | 4.16 | .350 | 1.57 | 9.1 | 5.2 | 7.2 | 75.2 | 76 | 40 | 35 | 10 | 43 | 60 | 0 | 7 | 1 | 0 | 0 | 3 | 3 | 4.97 |
| SP | Priester, Q.Priester, Quinn >> | 24 | 2025 | R | 48 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Kremer, D.Kremer, Dean >> | 29 | 2025 | R | 52 | 19 | 0 | 3 | 4 | 6.17 | .375 | 1.80 | 9.4 | 7.0 | 11.3 | 23.1 | 24 | 16 | 16 | 2 | 18 | 29 | 0 | 1 | 3 | 0 | 0 | 0 | 1 | 3.96 |