| SP | Skubal, T.Skubal, Tarik >> | 28 | 2025 | L | 100 | 26 | 26 | 9 | 10 | 3.73 | .313 | 1.34 | 9.6 | 2.5 | 11.4 | 154.1 | 165 | 66 | 64 | 21 | 42 | 195 | 0 | 0 | 0 | 0 | 13 | 4 | 1 | 3.14 |
| SP | Gilbert, L.Gilbert, Logan >> | 28 | 2025 | R | 90 | 25 | 25 | 3 | 11 | 5.94 | .362 | 1.65 | 11.0 | 4.0 | 10.5 | 110.2 | 134 | 74 | 73 | 26 | 49 | 128 | 0 | 0 | 0 | 0 | 4 | 5 | 7 | 5.22 |
| SP | Sanchez, C.Sanchez, Cristopher † >> | 28 | 2025 | L | 80 | 25 | 25 | 13 | 8 | 4.44 | .291 | 1.22 | 8.6 | 2.3 | 8.7 | 144.0 | 138 | 73 | 71 | 24 | 37 | 139 | 3 | 0 | 0 | 2 | 12 | 2 | 0 | 4.05 |
| SP | Williams, G.Williams, Gavin >> | 25 | 2025 | R | 65 | 24 | 24 | 5 | 6 | 5.89 | .364 | 1.68 | 9.4 | 5.8 | 11.1 | 117.2 | 122 | 80 | 77 | 19 | 76 | 144 | 0 | 0 | 0 | 0 | 4 | 4 | 4 | 4.70 |
| RP | Kittredge, A.Kittredge, Andrew >> | 35 | 2025 | R | 84 | 68 | 0 | 10 | 3 | 4.54 | .313 | 1.37 | 9.6 | 2.8 | 12.7 | 75.1 | 80 | 38 | 38 | 9 | 23 | 106 | 0 | 2 | 3 | 0 | 0 | 0 | 1 | 2.65 |
| RP | Bednar, D.Bednar, David >> | 30 | 2025 | R | 79 | 71 | 0 | 2 | 2 | 4.03 | .343 | 1.55 | 9.7 | 4.3 | 11.5 | 76.0 | 82 | 40 | 34 | 9 | 36 | 97 | 0 | 14 | 1 | 0 | 0 | 1 | 1 | 3.45 |
| RP | Whitlock, G.Whitlock, Garrett >> | 29 | 2025 | R | 75 | 52 | 0 | 4 | 1 | 4.53 | .329 | 1.44 | 8.5 | 4.6 | 11.6 | 55.2 | 52 | 31 | 28 | 7 | 28 | 71 | 0 | 1 | 2 | 0 | 0 | 2 | 4 | 3.71 |
| RP | Estrada, J.Estrada, Jeremiah >> | 26 | 2025 | R | 64 | 49 | 0 | 0 | 4 | 5.16 | .329 | 1.45 | 9.0 | 4.2 | 11.6 | 52.1 | 52 | 32 | 30 | 9 | 24 | 67 | 0 | 4 | 1 | 0 | 0 | 1 | 3 | 4.12 |
| SP | Valdez, F.Valdez, Framber >> | 31 | 2025 | L | 59 | 24 | 0 | 4 | 2 | 4.95 | .336 | 1.46 | 9.4 | 3.8 | 8.5 | 91.0 | 95 | 51 | 50 | 9 | 38 | 86 | 0 | 0 | 0 | 0 | 0 | 5 | 3 | 3.81 |