| SP | Skubal, T.Skubal, Tarik >> | 28 | 2025 | L | 100 | 26 | 26 | 9 | 6 | 3.14 | .273 | 1.11 | 7.6 | 2.3 | 10.1 | 169.0 | 143 | 64 | 59 | 12 | 44 | 190 | 2 | 0 | 0 | 2 | 19 | 3 | 2 | 2.51 |
| SP | Crochet, G.Crochet, Garrett >> | 26 | 2025 | L | 88 | 25 | 25 | 7 | 12 | 4.83 | .315 | 1.36 | 9.0 | 3.3 | 12.0 | 139.2 | 139 | 76 | 75 | 25 | 51 | 185 | 1 | 0 | 0 | 1 | 13 | 3 | 2 | 3.84 |
| SP | Schwellenbach, S.Schwellenbach, Spencer >> | 25 | 2025 | R | 85 | 24 | 24 | 8 | 4 | 3.76 | .296 | 1.22 | 8.8 | 2.2 | 9.4 | 153.0 | 150 | 76 | 64 | 22 | 37 | 159 | 0 | 0 | 0 | 0 | 16 | 6 | 7 | 3.63 |
| SP | Luzardo, J.Luzardo, Jesus # >> | 27 | 2025 | L | 64 | 24 | 24 | 6 | 7 | 5.68 | .367 | 1.69 | 11.3 | 4.0 | 11.2 | 115.2 | 144 | 78 | 73 | 18 | 51 | 143 | 0 | 0 | 0 | 0 | 7 | 6 | 4 | 4.03 |
| RP | Iglesias, R.Iglesias, Raisel >> | 35 | 2025 | R | 80 | 25 | 0 | 1 | 0 | 3.00 | .314 | 1.38 | 9.4 | 3.0 | 9.0 | 24.0 | 25 | 10 | 8 | 3 | 8 | 24 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 3.63 |
| RP | Morejon, A.Morejon, Adrian >> | 26 | 2025 | L | 90 | 49 | 0 | 4 | 4 | 1.81 | .226 | 0.82 | 5.3 | 2.2 | 9.8 | 54.2 | 32 | 11 | 11 | 3 | 13 | 59 | 0 | 1 | 2 | 0 | 0 | 3 | 1 | 2.43 |
| RP | Estevez, C.Estevez, Carlos >> | 32 | 2025 | R | 71 | 36 | 0 | 6 | 1 | 3.66 | .302 | 1.22 | 8.8 | 2.3 | 9.9 | 39.1 | 38 | 18 | 16 | 5 | 10 | 43 | 0 | 2 | 4 | 0 | 0 | 3 | 2 | 3.46 |
| RP | Miller, S.Miller, Shelby >> | 34 | 2025 | R | 84 | 30 | 0 | 2 | 4 | 2.61 | .260 | 1.03 | 5.7 | 3.6 | 9.9 | 38.0 | 24 | 11 | 11 | 5 | 15 | 42 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 3.76 |
| RP | Newcomb, S.Newcomb, Sean >> | 32 | 2025 | L | 22 | 17 | 0 | 0 | 2 | 7.15 | .346 | 1.50 | 9.0 | 4.9 | 8.2 | 22.2 | 22 | 20 | 18 | 4 | 12 | 20 | 0 | 1 | 1 | 0 | 0 | 2 | 1 | 5.45 |
| SP | Castillo, L.Castillo, Luis >> | 32 | 2025 | R | 62 | 16 | 0 | 3 | 2 | 4.34 | .306 | 1.27 | 8.7 | 2.7 | 8.4 | 56.0 | 54 | 34 | 27 | 6 | 17 | 52 | 0 | 0 | 0 | 0 | 0 | 3 | 3 | 3.61 |