| SP | Brown, H.Brown, Hunter † >> | 26 | 2025 | R | 92 | 28 | 28 | 8 | 10 | 3.72 | .289 | 1.19 | 7.8 | 2.9 | 11.0 | 174.1 | 151 | 88 | 72 | 19 | 57 | 213 | 0 | 0 | 0 | 0 | 14 | 5 | 0 | 3.04 |
| SP | Gausman, K.Gausman, Kevin >> | 34 | 2025 | R | 82 | 26 | 26 | 6 | 10 | 4.14 | .344 | 1.51 | 9.8 | 3.8 | 9.4 | 158.2 | 172 | 78 | 73 | 16 | 67 | 165 | 1 | 0 | 0 | 0 | 12 | 11 | 3 | 3.71 |
| SP | Lodolo, N.Lodolo, Nick >> | 27 | 2025 | L | 75 | 26 | 26 | 6 | 13 | 4.43 | .322 | 1.40 | 10.4 | 2.2 | 9.7 | 142.1 | 164 | 81 | 70 | 22 | 35 | 153 | 0 | 0 | 0 | 0 | 8 | 4 | 0 | 3.68 |
| SP | Quintana, J.Quintana, Jose >> | 36 | 2025 | L | 34 | 26 | 26 | 8 | 10 | 5.82 | .363 | 1.67 | 10.8 | 4.3 | 7.0 | 137.2 | 164 | 90 | 89 | 25 | 66 | 107 | 0 | 0 | 0 | 0 | 6 | 5 | 3 | 5.36 |
| SP | Scherzer, M.Scherzer, Max >> | 41 | 2025 | R | 32 | 29 | 25 | 4 | 13 | 5.71 | .350 | 1.59 | 10.5 | 3.9 | 7.6 | 132.1 | 154 | 93 | 84 | 27 | 57 | 111 | 0 | 1 | 0 | 0 | 5 | 3 | 3 | 5.34 |
| RP | Suarez, R.Suarez, Robert >> | 34 | 2025 | R | 92 | 85 | 0 | 6 | 3 | 4.05 | .335 | 1.47 | 10.4 | 3.0 | 10.8 | 106.2 | 122 | 52 | 48 | 15 | 35 | 127 | 0 | 2 | 6 | 0 | 0 | 4 | 1 | 3.55 |
| RP | Keller, B.Keller, Brad † >> | 29 | 2025 | R | 91 | 87 | 0 | 7 | 2 | 2.12 | .286 | 1.16 | 6.9 | 3.6 | 11.2 | 114.2 | 88 | 33 | 27 | 10 | 45 | 142 | 0 | 4 | 3 | 0 | 0 | 5 | 1 | 2.96 |
| RP | Treinen, B.Treinen, Blake >> | 37 | 2025 | R | 11 | 57 | 0 | 3 | 4 | 7.48 | .409 | 2.04 | 11.3 | 7.2 | 11.1 | 55.1 | 69 | 50 | 46 | 9 | 44 | 68 | 0 | 6 | 5 | 0 | 0 | 2 | 1 | 5.16 |
| RP | Scott, T.Scott, Tayler >> | 33 | 2025 | R | 3 | 55 | 0 | 3 | 3 | 6.63 | .402 | 2.00 | 10.9 | 7.1 | 8.1 | 57.0 | 69 | 46 | 42 | 18 | 45 | 51 | 0 | 7 | 2 | 0 | 0 | 1 | 0 | 7.74 |