| SP | Skubal, T.Skubal, Tarik $$ >> | 28 | 2025 | L | 100 | 12 | 12 | 5 | 2 | 4.78 | .284 | 1.16 | 8.2 | 2.3 | 10.8 | 79.0 | 72 | 42 | 42 | 9 | 20 | 95 | 0 | 0 | 0 | 0 | 5 | 2 | 1 | 2.91 |
| SP | Perez, E.Perez, Eury # >> | 22 | 2025 | R | 89 | 12 | 12 | 3 | 5 | 4.65 | .293 | 1.23 | 7.7 | 3.3 | 10.3 | 62.0 | 53 | 32 | 32 | 11 | 23 | 71 | 0 | 0 | 0 | 0 | 2 | 1 | 1 | 4.18 |
| SP | Glasnow, T.Glasnow, Tyler $ >> | 31 | 2025 | R | 86 | 12 | 12 | 4 | 4 | 4.35 | .301 | 1.27 | 7.5 | 3.9 | 9.6 | 62.0 | 52 | 31 | 30 | 9 | 27 | 66 | 0 | 0 | 0 | 0 | 3 | 1 | 0 | 4.11 |
| SP | Nelson, R.Nelson, Ryne >> | 27 | 2025 | R | 79 | 12 | 11 | 3 | 2 | 5.13 | .297 | 1.23 | 7.8 | 3.3 | 8.2 | 54.1 | 47 | 31 | 31 | 10 | 20 | 49 | 0 | 1 | 0 | 0 | 1 | 2 | 0 | 4.81 |
| SP | Kelly, M.Kelly, Merrill >> | 36 | 2025 | R | 69 | 11 | 11 | 3 | 4 | 5.98 | .371 | 1.70 | 10.7 | 4.8 | 8.1 | 58.2 | 69 | 39 | 39 | 10 | 31 | 52 | 0 | 0 | 0 | 0 | 4 | 4 | 0 | 5.26 |
| RP | Kittredge, A.Kittredge, Andrew >> | 35 | 2025 | R | 84 | 31 | 0 | 4 | 1 | 1.10 | .255 | 1.02 | 6.8 | 2.4 | 10.5 | 41.0 | 31 | 8 | 5 | 4 | 11 | 48 | 0 | 3 | 3 | 0 | 0 | 0 | 1 | 2.73 |
| RP | Iglesias, R.Iglesias, Raisel >> | 35 | 2025 | R | 80 | 26 | 0 | 4 | 1 | 6.75 | .314 | 1.33 | 9.4 | 2.6 | 7.5 | 24.0 | 25 | 18 | 18 | 2 | 7 | 20 | 0 | 1 | 3 | 0 | 0 | 1 | 0 | 3.42 |
| RP | Henriquez, R.Henriquez, Ronny >> | 25 | 2025 | R | 78 | 27 | 0 | 2 | 0 | 1.65 | .281 | 1.13 | 6.3 | 4.0 | 11.3 | 27.1 | 19 | 6 | 5 | 0 | 12 | 34 | 0 | 5 | 0 | 0 | 0 | 1 | 2 | 1.93 |
| RP | Santillan, T.Santillan, Tony >> | 28 | 2025 | R | 73 | 18 | 0 | 2 | 0 | 1.47 | .267 | 1.04 | 6.0 | 3.5 | 8.5 | 18.1 | 12 | 3 | 3 | 1 | 7 | 17 | 0 | 2 | 0 | 0 | 0 | 1 | 0 | 3.17 |
| RP | Holton, T.Holton, Tyler >> | 29 | 2025 | L | 63 | 40 | 0 | 2 | 2 | 6.41 | .355 | 1.65 | 11.4 | 3.8 | 8.0 | 26.2 | 33 | 20 | 19 | 8 | 11 | 23 | 0 | 2 | 4 | 0 | 0 | 0 | 0 | 6.50 |
| SP | Kirby, G.Kirby, George >> | 27 | 2025 | R | 61 | 11 | 0 | 5 | 0 | 3.69 | .307 | 1.29 | 9.3 | 2.6 | 10.2 | 31.2 | 32 | 14 | 13 | 8 | 9 | 35 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 5.06 |