| SP | Skubal, T.Skubal, Tarik >> | 28 | 2025 | L | 100 | 29 | 29 | 8 | 9 | 2.58 | .268 | 1.09 | 7.6 | 2.2 | 9.8 | 202.2 | 171 | 59 | 58 | 21 | 49 | 221 | 2 | 0 | 0 | 0 | 23 | 3 | 6 | 2.94 |
| SP | Nelson, R.Nelson, Ryne >> | 27 | 2025 | R | 79 | 28 | 28 | 4 | 8 | 5.24 | .336 | 1.45 | 10.2 | 2.9 | 7.9 | 123.2 | 139 | 75 | 72 | 18 | 40 | 108 | 0 | 0 | 0 | 0 | 4 | 9 | 1 | 4.34 |
| SP | Kelly, M.Kelly, Merrill >> | 36 | 2025 | R | 69 | 28 | 28 | 14 | 10 | 4.61 | .308 | 1.30 | 8.7 | 3.1 | 7.8 | 162.0 | 156 | 86 | 83 | 20 | 55 | 140 | 0 | 0 | 0 | 0 | 12 | 5 | 1 | 3.99 |
| SP | Bello, B.Bello, Brayan >> | 26 | 2025 | R | 55 | 27 | 27 | 9 | 7 | 5.19 | .340 | 1.50 | 9.9 | 3.7 | 6.8 | 147.1 | 161 | 88 | 85 | 27 | 60 | 111 | 0 | 0 | 0 | 0 | 8 | 7 | 2 | 5.24 |
| RP | Kittredge, A.Kittredge, Andrew >> | 35 | 2025 | R | 84 | 94 | 0 | 7 | 1 | 3.59 | .302 | 1.27 | 8.8 | 2.7 | 10.7 | 87.2 | 85 | 35 | 35 | 9 | 26 | 103 | 0 | 0 | 1 | 0 | 0 | 3 | 2 | 2.98 |
| RP | Strahm, M.Strahm, Matt >> | 33 | 2025 | L | 73 | 97 | 0 | 5 | 2 | 3.06 | .277 | 1.14 | 7.3 | 3.0 | 10.9 | 85.1 | 69 | 30 | 29 | 14 | 28 | 103 | 0 | 2 | 3 | 0 | 0 | 1 | 5 | 3.74 |
| RP | Coulombe, D.Coulombe, Daniel >> | 35 | 2025 | L | 65 | 85 | 0 | 4 | 3 | 2.61 | .322 | 1.40 | 9.3 | 3.4 | 9.8 | 82.2 | 85 | 24 | 24 | 8 | 31 | 89 | 0 | 2 | 4 | 0 | 0 | 2 | 2 | 3.30 |
| SP | Glasnow, T.Glasnow, Tyler >> | 31 | 2025 | R | 86 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Taillon, J.Taillon, Jameson >> | 33 | 2025 | R | 74 | 20 | 0 | 3 | 0 | 1.66 | .260 | 1.05 | 6.9 | 2.6 | 7.8 | 38.0 | 29 | 8 | 7 | 4 | 11 | 33 | 0 | 3 | 2 | 0 | 0 | 0 | 0 | 3.50 |
| SP | Singer, B.Singer, Brady >> | 28 | 2025 | R | 59 | 29 | 0 | 6 | 3 | 5.40 | .338 | 1.53 | 7.8 | 6.0 | 7.5 | 30.0 | 26 | 18 | 18 | 3 | 20 | 25 | 0 | 3 | 1 | 0 | 0 | 0 | 0 | 4.63 |