| SP | Skubal, T.Skubal, Tarik >> | 28 | 2025 | L | 100 | 20 | 20 | 5 | 8 | 3.88 | .310 | 1.31 | 10.0 | 1.7 | 10.7 | 130.0 | 145 | 59 | 56 | 12 | 25 | 154 | 0 | 0 | 0 | 0 | 11 | 5 | 2 | 2.52 |
| SP | Gilbert, L.Gilbert, Logan # >> | 28 | 2025 | R | 90 | 19 | 19 | 9 | 4 | 3.86 | .279 | 1.09 | 7.8 | 2.0 | 12.0 | 105.0 | 91 | 45 | 45 | 11 | 23 | 140 | 0 | 0 | 0 | 0 | 12 | 8 | 9 | 2.58 |
| SP | Cameron, N.Cameron, Noah >> | 25 | 2025 | L | 78 | 18 | 18 | 7 | 7 | 3.97 | .307 | 1.27 | 8.1 | 3.4 | 8.6 | 106.2 | 95 | 52 | 47 | 8 | 40 | 101 | 0 | 0 | 0 | 0 | 8 | 7 | 1 | 3.41 |
| SP | Abbott, A.Abbott, Andrew >> | 26 | 2025 | L | 67 | 18 | 18 | 4 | 10 | 5.89 | .341 | 1.55 | 10.5 | 3.5 | 8.3 | 94.2 | 110 | 64 | 62 | 14 | 37 | 87 | 0 | 0 | 0 | 0 | 7 | 0 | 2 | 4.27 |
| SP | Kirby, G.Kirby, George >> | 27 | 2025 | R | 61 | 18 | 18 | 3 | 7 | 7.50 | .382 | 1.86 | 12.6 | 4.1 | 8.3 | 84.0 | 118 | 72 | 70 | 12 | 38 | 77 | 0 | 0 | 0 | 0 | 4 | 0 | 3 | 4.38 |
| RP | Keller, B.Keller, Brad >> | 29 | 2025 | R | 91 | 57 | 0 | 1 | 3 | 3.42 | .339 | 1.50 | 10.2 | 3.5 | 9.9 | 52.2 | 59 | 20 | 20 | 4 | 20 | 57 | 0 | 0 | 3 | 0 | 0 | 2 | 0 | 3.08 |
| RP | Strahm, M.Strahm, Matt >> | 33 | 2025 | L | 73 | 50 | 0 | 1 | 0 | 4.45 | .336 | 1.45 | 8.7 | 4.5 | 11.3 | 32.1 | 31 | 16 | 16 | 3 | 16 | 40 | 0 | 2 | 0 | 0 | 0 | 2 | 2 | 3.41 |
| SU | Jansen, K.Jansen, Kenley >> | 37 | 2025 | R | 89 | 36 | 0 | 4 | 0 | 2.78 | .302 | 1.30 | 9.3 | 2.5 | 9.0 | 32.1 | 33 | 10 | 10 | 1 | 9 | 32 | 0 | 1 | 2 | 0 | 0 | 0 | 0 | 2.25 |
| CL | Miller, M.Miller, Mason >> | 26 | 2025 | R | 98 | 37 | 0 | 0 | 4 | 2.97 | .310 | 1.35 | 8.8 | 3.5 | 11.5 | 36.1 | 35 | 12 | 12 | 1 | 14 | 46 | 0 | 22 | 3 | 0 | 0 | 0 | 1 | 1.97 |